A-Adrenoreceptor antagonist

Prazosin (hydrochloride), 2-[4-(fur-2-oyl)piperazin-l-yl]-6,7-dimethoxy-4-quinazolinamine, a-adrenoreceptor antagonist antihypertensive [19216-56-9],... 

Lee E, Lee C. Clinical comparison of selective and non-selective a -adrenoreceptor antagonists in benign prostatic hyperplasia Studies on tamsulosin in a fixed dose and terazosin in increasing doses. Br J Urol... 

A vast array of structurally unrelated compounds interacts with a I-adrenoreceptor subtypes, which makes it inherently difficult to determine the structural requirements leading to receptor subtypes selectivity (Ruffolo et al., 1995 Leonard et al., 1996 Kenny et al., 1997). The majority of a,-adrenoreceptor antagonists displays a competitive mechanism of action and belongs to a variety of different structural classes such as yohimbanes, ergot alkaloids, quinazolines, A-arylpiperazines, imidazolines, phenylalkylamines, benzodioxanes, indoles, 1,4-dihydro-pyridines, hetero-fused 3-benzazepines, dibenzoquino-lizines. 

Prazosin (1), the prototype of quinazoline-bearing compounds, is a selective a,-adrenoreceptor antagonist widely used as a pharmacological tool for a-adrenoreceptor sub-types characterization and as an effective agent in the... 

Benzodioxanes represent one of the oldest and best known classes of a-adrenoreceptor antagonists whose chemical structure incorporates a l,4-benzodioxan-2-yl moiety as the main feature (Melchiorre and Belleau, 1981). WB 4101 (21) is the prototype of a (-adrenoreceptor an-... 

Quaglia, W., Pigini, M., Giannella, M, Melchiorre, C., 1990. 3-Phenyl analogues of 2-[[[2-(2,6-dimethoxyphenoxy)ethyl]amino]methyl]-1,4-benzodioxan (WB 4101) as highly selective a,-adrenoreceptor antagonists. J. Med. Chem. 33, 2946-2948. 

They usually exert a generalised direct vasodilator effect on all muscular walled vessels. They are found to reduce vasoconstriction and enhance tissue perfusion. They are also termed as either a-adrenoreceptor antagonists or nonselective a-antagonists. 

The drug is anon seleetive a-adrenoreceptor antagonist and the blockade caused is reversible. Besides, exhibiting a-bloeking activity it possesses a plethora of other pharmacological actions, namely ... 

---