02-Adrenoreceptors agonist

Phentolamine (87), WB 4101 (88), and the site directed alkylatiag agent, chloroethylclonidine (CEC) (89) have been traditionally used to define a -receptors. Table 6 Hsts the various catecholamines and adrenoreceptor agonists and antagonists. 

The (R)-amino ketone is hydrogenated enantioselectively by a neutral complex [ (S)-(i )-BPPFOH RhCl]2 to give the (R,R)-isoproterenol analogue, a compound which has been shown to possess very potent /9-adrenoreceptor agonistic activity... 

Salbutamol is a beta-adrenoreceptor agonist that is used in asthma or chronic obstructive pulmonary disease in order to exert bronchodilation. Side-effects... 

One of the first 8-adrenoreceptor agonists used both currently and in the past as a bron-cholytic is epinephrine or adrenaline, isoproterenol, and especially ephedrine. In treatment and prevention of obstructive respiratory tract diseases, other j3-adrenoreceptor agonists also are used, such as isoetharine, terbutaUne, albuterol, metaproterenol, and also those described in this section—fenoterol (23.3.16), pirbuterol (23.3.22), and procaterol (23.3.25). 

Brimonidine tartrate Alpha 2-adrenoreceptor agonist, adjunct in glaucoma... 

There has been considerable interest in the enantiomers of salmeterol (2). Salmeterol (2) is a long acting, potent (32 adrenoreceptor agonist. The (7 )-enantiomer is more potent than the (S)-enantiomer, however, it has been recently claimed that the (S)-enantiomer has a higher selectivity for P2 receptors and thus exhibited fewer side-effects than the (/ )-enantiomer or the racemate. ... 

Szot P, Lester M, Laughlin ML, Palmiter RD, Liles LC, Weinshenker D (2004) The anticonvulsant and proconvulsant effects of a2-adrenoreceptor agonists are mediated by distinct populations of a2A-adrenoreceptors. Neuroscience 126 795-803... 

As described previously, activation of P-adrenoreceptors leads to the accumulation of cAMP and activation of PKA. This suggests that the effects of NE and other P-adrenoreceptors agonists are mainly mediated via activation of PKA. This is supported by the fact, that the effects of NE is mimicked by P agonists or by compounds that increase... 

Depletion of NE may cause deterioration of AD pathology in different animal models (Heneka et al., 2002) (Kalinin et al., 2007) (Heneka et al., 2006). Animals who received amyloid-P injections into the cortex and chronic DSP4 to induce LC neuronal cell death led to induction of inflammatory changes within the CNS of AD animals. An increase in iNOS, IL-ip, and IL-6 expression compared to control animals was measured in the brain. However, COX-2 expression was transiently reduced in the AD animals. Co-injection with NE or the P-adrenoreceptors agonist isoproterenol attenuated the inflammatory response in the amyloid-P and DSP4 injected animals. The inflammatory response caused by NE depletion seems to be due to reduced levels of NF-kB inhibitory IkB proteins and of heat shock protein 70 (Heneka et al., 2003). 

Catapres Clonidine HC1 USP 0.1, 0.2, 0.3 mg Tablet Hypertension Alpha-adrenoreceptor agonist Colloidal silicon dioxide, corn starch, dibasic calcium phosphate, gelatin, glycerin, lactose, magnesium stearate, methylparaben, propylparaben Boehriner Ingelheim (Mylan)... 

Drugs for Obstructive Airway Diseases Selective Beta-2-adrenoreceptor Agonists... 

Table 2 Effect of entry 1 and reference phenylephrine as a1L-adrenoreceptor agonists in the treatment of stress incontinence in women...

Benzimidazoles, (II), and benzothiazole derivatives, (III), effective as a1L-adrenoreceptor agonists were prepared by Jeon (2) and used in treating incontinence in women. 

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