03-Adrenergic receptors characterization

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In the central nervous system muscarinic acetylcholine receptors are more abundant than nicotinic receptors. They consist of single-chain proteins of mass 70 kDa. They are not ion channels but are 7-helix receptors homologous in sequence with P-adrenergic receptors (Fig. 11-6) and with rhodopsin.648 Five different subtypes (M1-M5) have been characterized. 

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Hillman KL, Doze VA, Porter JE. 2005. Functional characterization of the beta-adrenergic receptor subtypes expressed by CA1 pyramidal cells in the rat hippocampus. J Pharmacol Exp Ther 314 561-567. 

Biochemical and biophysical characterization of rhodopsin and the adrenergic receptors have identified residues near the cytoplasmic ends of TMIII and TMVI as important constraints on receptor structure and function. In the rhodopsin structure, the conserved E/DRYmotif found in TMIII is a central feature of the interface with TMVI. This structural motif in TMIII has been referred to as a functional microdomain because of its demonstrated functional significance in numerous GPCRs including the fi opiod receptor, 5-hydroxytryptamine2A receptor, ml muscarinic... 

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