Receptors 7-helix

Tyukhtenko S, Tiburu EK, Deshmukh L, Vinogradova O, Janero DR, Makriyannis A (2009) NMR solution structure of human cannabinoid receptor-1 helix 7/8 peptide candidate electrostatic interactions and microdomain formation. Biochem Biophys Res Commun 390 441 146... 

Figure 5.23 The globular head of the hemagglutinin subunit Is a distorted jelly roll stmcture (a). P strand 1 contains a long Insertion, and P strand 8 contains a bulge in the corresponding position. Each of these two strands is therefore subdivided Into shorter P strands. The loop region between P strands 3 and 4 contains a short a helix, which forms one side of the receptor binding site (yellow circle). A schematic diagram (b) Illustrates the organization of the p strands into a jelly roll motif.

Figure 5.27 Schematic representation of a model for the conformational change of hemagglutinin that at low pH brings the fusion peptide to the same end of the molecule as the receptor binding site. The fusion peptide (purple) is at the end of heUx A about 100 A away from the receptor binding site in the high pH form. In the low pH fragment this region of helix A has moved about 100 A towards the area where the receptor binding sites are expected to be in the intact hemagglutinin molecule. (Adapted from D. Stuart, Nature 371 19-20, 1994.)...

Figure 10.11 Sequence-specific interactions between DNA (yellow) and the recognition helix (red) of the glucocorticoid receptor. Three residues, Lys 461, Val 462 and Arg 466 make specific contacts with the edges of the bases In the major groove.

G proteins are molecular amplifiers for a large number of seven-trans-membrane helix receptors that regulate responses like vision, smell and stress response. They are heterotrimeric molecules, Gap, that dissociate into membrane-bound Ga and Gpy signal transmitters upon activation of the receptor. 

Seven transmembrane helix receptors Heptahelical receptors Serpentine receptors... 

Kleinau G, Claus M, Jaeschke H et al (2007) Contacts between extracellular loop two and transmembrane helix six determine basal and hormone induced activity of the thyroid stimulating hormone receptor. J Biol Chem 282(1 ) 518-25... 

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