Adrenaline lipid mobilization

Not only the nutritional status but also the age of animals influences the lipid-mobilizing reactions Dury (1961) and Jelinkova-Tenorovd and Hr a (1963) found a marked falling off of the adrenalin effect in aged animals. 

Phentolamine antagonizes the lipid-mobflizing effects of adrenaline and noradrenaline in vivo and in vitro (Schotz and Page, 1960 Wenke et al., 1961 Stock and Westermann, 1965). Furthermore, phentolamine has been reported to exert a somewhat feeble lipid-mobilizing effect in vivo (Boshart et al., 1964) and in vitro (Wenke et al., 1963). 

The neurohormonal control of lipid metabolism chiefly affects the mobilization and synthesis of triglycerides in the fat tissue. The lipolysis in tissues is dependent upon the activity of triglyceride lipase. All the regulators that favour the conversion of the inactive (nonphosphorylated) lipase to the active (phosphoiylated) one, stimulate the lipolysis and the release of fatty acids into the blood. Adrenalin... 

The fatty acids for P-oxidation are derived from storage triacylglycerols or the turnover of membrane lipids. The mobilization of fatty acids from adipocytes occurs when the diet or glycogen reserves are insufficient to satisfy the calorific requirements of tissues. Hormonally controlled lipases systematically hydrolyse the ester bonds of triacylglycerols to release fatty acids and glycerol. This lipolysis is mediated by cAMP following the interaction of, e.g. adrenaline or glucagon, with their specific receptors in the adipocyte plasma membrane (Section 10.7). 

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