ADME/Tox profiling

Herbst et al.2 described automated high-throughput ADME/Tox profiling for optimization of preclinical candidates, a Profiling Toolkit enables researchers to request profiles, track progress, receive notification when the requests have been filled, and view data. Automated systems and bar coding improve efficiency, help track compound and plate locations, and create audits trail of the profiling process. 

Herbst, J.J. and Dickinson, K. 2005. Automated high-throughput ADME/Tox profiling for optimization of preclinical candidate success. Am. Pharm. Rev. 8 96. 

DeWitte, R.S. and Robins, R.H. 2006.A hierarchical screening methodology for physicochemical/ ADME/Tox profiling. Expert Opin. Drug Metab. Toxicol. 2 805. 

Gamache, P., Smith, R., McCarthy, R., Waraska, J., and Acworth, I. N. (2003b). ADME/Tox profiling using coulometric electrochemistry and electrospray ionization mass spectrometry. Spectroscopy 18 14-21. 

Ion channels are membrane proteins that play essential roles in cell physiology and pharmacology (also see Chapter 13). Consequently they have been identified as potential targets for novel therapeutic compounds in a range of disease areas [76], such as cardiovascular disorders, central and peripheral nervous system disorders, and metabolic disorders. Unfortunately, they are also inextricably linked with the absorption, distribution, metabolism, and excretion/ toxicology (ADME/Tox) profile of other therapeutic compounds—often through unforeseen drug-ion channel interactions [77]. 

Kerns, E.H. (2008) Editorial high throughput in vitro ADME/tox profiling for drug discovery. Current Drug Metabolism, 9, 845-846. 

See for example CEREP services for pharmacology ADME-Tox profiling under http //www.cerep.fr/cerep/users/ pages/ProductsServices/pharmacoetADME. asp (accessed on 22th of August 2015) for more details. 

Sophisticated ADME/Tox models and empirical rules derived from increasing amounts of pre-clinical profiling and safety pharmacology data... 

The fully automated computational procedure is a valuable ne v tool in virtual screening and in early ADME-Tox, vhere drug safety and metabolic profile patterns must be evaluated in order to enhance and streamline the process of developing neiv drug candidates. 

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