Adjacent amine group

The second reaction took place during drying of the membrane at 110°C. The residual polyethylenlmine under the polyamide surface skin was crosslinked by elimination of ammonia between adjacent amine groups (see Reaction II). 

Figure 16 Zn" addressed intramolecular electron transfer involving (n,Q) -substituents of a linear tetramine. Spectrofluorimetric titration by standard base of disubstituted tetramines 11 (diamonds) and 12 (circles), in aqueous MeCN, in presence of 1 equiv. of Zn . Triangles refer to the titration experiment with reference system 4. For systems 11 and 12, /p keeps decreasing at pH >4.5, since the eT process from the adjacent amine group of An is replaced by an intracomplex eT process involving either the -NMc2 (11) or the -NO2 (12) substituent.

This polymer, having two adjacent amine groups, is capable of complexing a heavy metal ion such as Ag as shown above. The formation constant was 2.8 x 10, which is about four orders of inagnitude smaller than that of the unobstructed complex, Ag(NH3)2 (1,8 X 10 °). This might have resulted from the steric hindrance of the two amine groups within the polymer matrix. The amount of collected heavy metal ions by the electrode for a given time was determined by voltammetric analysis at the polymer modified. Also, the conductivity of the polymer complexed with Ag ... 

Synthesis of Imidazoles and Imidazole-Like Cores. The synthesis of imidazoles starting from resin-bound amino acids usually involves the linkage of adjacent amine groups of a peptide bond through the treatment of phosphoryl chloride. The phosphoryl chloride plays the role of the dehydration reagent in the conversion of an in situ formed imidoyl chloride intermediate to the desired imidazole scaffold. 

Scheme 2.20 Reaction of alcohol, acetal, olefin, and amide bearing adjacent amine group.

Fabric Softeners, Surfactants and Bleach Activators. Mono- and bisamidoamines and their imidazoline counterparts are formed by the condensation reaction of one or two moles of a monobasic fatty acid (typically stearic or oleic) or their methyl esters with one mole of a polyamine. Imidazoline formation requires that the ethyleneamine have at least one segment in which a secondary amine group Hes adjacent to a primary amine group. These amidoamines and imidazolines form the basis for a wide range of fabric softeners, surfactants, and emulsifiers. Commonly used amines are DETA, TETA, and DMAPA, although most of the polyethylene and polypropane polyamines can be used. 

The loss of the TBDMS group during LiAlH4 reductions has been observed in cases where there is an adjacent amine or hydroxyl. - ... 

Proteins are polyamides formed by the polymerization, through amide linkages, of a-amino acids. Three of the 25-30 important natural a-amino acids are shown in Figure 18-13. Each acid has an amine group, —NHj, attached to the a-carbon, the carbon atom immediately adjacent to the carboxylic acid group. 

The principal side reaction to epoxide coupling is hydrolysis. Particularly at acid pH values, the epoxide ring can hydrolyze to form adjacent hydroxyls. This diol can be oxidized with periodate to create a terminal aldehyde residue with loss of one molecule of formaldehyde (Chapter 1, Section 4.4). The aldehyde then can be used in reductive amination reactions. The reaction of an epoxide group with an ammonium ion generates a terminal primary amine group that also can be used for further derivatization. 

The link between adjacent units or monomers in a polypeptide is formed in a condensation reaction between the amine group of one amino acid and the carboxylic acid group of another with the elimination of H20 molecules. These links are called peptide bonds. 

Thus, the anticholinergic activity of the alkaloid hyoscyamine is almost entirely confined to the (—)-isomer, and the (+)-isomer is almost devoid of activity. The racemic ( )-form, atropine, has approximately half the activity of the laevorotatory enantiomer. An anticholinergic drug blocks the action of the neurotransmitter acetylcholine, and thus occupies the same binding site as acetylcholine. The major interaction with the receptor involves that part of the molecule that mimics acetylcholine, namely the appropriately positioned ester and amine groups. The chiral centre is adjacent to the ester, and also influences binding to the receptor. 

---