Adipogenic Potential of Other Adenoviruses

The adipogenic potential of Ad-36 is not shared by all adenoviruses. Avian adenovirus CELO or human adenoviruses type 2 or 31 did not promote adiposity in animal models (Atkinson et al., 2002 Dhurandhar et al., 2000). Unlike Ad-36, Ad-2 and Ad-31 did not show association with human obesity. For Ad-31 and Ad-2 the antibody prevalence between the obese and the nonobese subjects was similar (76% vs SU/o for Ad-2 and 70% and 80% for Ad-31). BMIs and serum lipids were virtually identical for AB- - and AB— subjects (Atkinson et al., 2005). Moreover, almost equal distribution of seropositivity among the obese and nonobese subjects for Ad-2 and Ad-31 suggested that the greater prevalence of Ad-36 antibodies in obese subjects is not a result of obesity. 

Of the 50 known serotypes of human adenovirus, Ad-36, Ad-37, and Ad-5 are adipogenic and Ad-2 and Ad-31 are not adipogenic. Adipogenic 

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