Adhesion to Tissue

Knutton S, Baldwin T, Williams PH, McNeish AS Actin accumulation at sites of bacterial adhesion to tissue culture cells Basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli. Infect Immun 1989 57 1290-1298. 

Fig. 2.31 Cross-sectional view of particulate dressing in Fig. 2.30 and demonstrating adhesion to tissue, xlO magnification...

Poly(butyral-co-vinyl acetate-co-vinyl alcohol) - A terpolymer with greater water resistance than polyvinyl acetate, but good adhesion to tissue when applied in ethanol solution. 

Plasma treatment is widely used commercially for polymer surface modification. Plasma discharge treatments are used to improve adhesiveness and printing properties, to improve cell adhesion to tissue culture substrates (1 ) and to etch or clean the surfaces of materials (removal of photoresist materials on semiconductors, for example ( ). The surface characterization of plasma-modified surfaces is important in order to provide greater insight into how the properties are changed. 

Interesting polymers have been produced by copolymerization of siloxanes with other polymers. For example, dimethylsiloxane was copolymerized with ethylene oxide and methyl methacrylate to create a series of polymers with controlled permeability to hydrophilic or hydrophobic steroids, enhanced mechanical properties, and improved adhesion to tissues [15-17]. 

Nikolovski, J., and Mooney, D. J. (20(X)), Smooth muscle cell adhesion to tissue engineering scaffolds. Biomaterials 21(20) 2025-2032. 

To overcome the issues of limited durability and poor adhesion to tissue. Pan et al. incorporated nano-hydroxyapatite (nano-HA) into the PVA-C matrix... 

The reaction is schematically shown in Fig. 2. An example of gelation time is shown in Fig. 3. Activated poly(L-glutamic acid) is stable in the presence of water if it is under appropriate conditions. The gel obtained has good adhesion to tissue and exhibits excellent hemostatic capability. This gel is absorbed by the body. However, biosafety... 

Since the bond strength of fibrin adhesives to tissue is not very high (Chivers and Wolowacz... 

This agent was approved by the FDA in May of 2000 and is the first tissue adhesive to be specifically approved for use on lung parenehyma. It is extremely strong and has excellent adherence strength on the surface of the lung. Approval... 

Levy, O.L.. Martinowilz, U., Oran, A., Tauber, C. and Horoszowski, H., The use of fibrin tissue adhesive to reduce blood loss and the need for blood transfusion after total knee arthroplasty a prospective, randomized, mullicenter study. J. Bone Joint Surg.. 81A. 1580 (1999). 

There are many obstacles to permanent adhesion under oral conditions. The substrate is a biological tissue and subject to change, and the presence of moisture represents the worst kind of situation for adhesion. Water is the great barrier to adhesion. It competes for the polar surface of tooth material against any potential polymer adhesive. It also tends to hydrolyse any adhesive bond formed. These twin obstacles gave rise to considerable doubt as to whether materials adhesive to tooth material could be developed at all (Cornell, 1961). 

Both microbial and host factors are important determinants in the development of osteomyelitis.2,3,9 Staphylococcus species possess bacterial adhesions, which promote their attachment to tissues and foreign devices. As such, S. aureus... 

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