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Adenosine molecular recognition

Further computational studies on adenines and adenosines concern the reaction mechanism of ribonuclease A with cytidyl-3,5 -adenosine [99BP697] and the molecular recognition of modified adenine nucleotides [99JMC5338]. [Pg.65]

Kunitake and coworkers experimentally investigated the effect of interface size on molecular recognition efficiency with a guanidinium-phosphate interaction (Fig. 2.4). Binding constants of aqueous phosphates such as adenosine monophosphate (AMP) to a monolayer of a guanidinium amphiphile were determined to be in the range of 106... [Pg.13]

Structurally, NADP differs from NAD only by a phosphate group esterified at the 2 C of the adenosine ribose, a difference which is reflected in the enzymatic roles NAD-dependent dehydrogenases are mostly involved in catabolic reactions, while NADP-specific enzymes are usually confined to biosynthetic pathways (1). The marked specificities displayed by dehydrogenases towards NAD and NADP have provided attractive model systems to understand the process of molecular recognition by protein engineering. [Pg.809]

The induced-fit mechanism exists not only in the molecular recognition process of cyclodextrins but also in that of other synthetic receptors. Rebek and coworkers introduced a family of receptors designed to bind adenosine derivatives within a pocket formed through induced fit. " Also, Schneider et al. described a configurational isomer with three different forms as a function of pjj[23] (Fig. 9). On complexing with ammonium derivatives, the configurational isomer could change from one... [Pg.720]

Cao s group in 2011 designed an ECL biosensor based on the construction of triplex DNA for the detection of adenosine which employs an aptamer as a molecular recognition element and quenches ECL of Ru(bpy)3 by ferrocene monocarboxylic acid (FcA) G ig. 6.5). In the presence of adenosine, the aptamer sequence (Ru-DNA-1) more likely forms the aptamer—adenosine complex with hairpin configuration and the switch of the DNA-1 occurs in conjunction with the... [Pg.111]

What is dramatically evident for L-Trp is the CICS values for Hj (A8 = -0.34) Hg (A8 = -0.15) Hf (A8 = -0.07) and Hg (A5 = -0.12), which were diametrically opposite to the previously reported Cp Rh-2 -deoxyadenosine cyclic trimer molecular recognition studies with host 1, where no upheld CICS for these designated protons were observed in that process, the indole phenyl group was found inside the hydrophobic receptor, while the hydrophilic aromatic amino acid NH3 and COO groups were outside in the water media, and the chiral C-H attached to these groups, as well as the adjacent asymmetric C H2, were not affected by the magnetic anisotropy of the inner shell of the host adenosine ligands. [Pg.335]

XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev 53 527-552 Furlong T, Pierce K, Selbie L, Shine J (1992) Molecular characterization of a human brain adenosine A2 receptor. Brain Res Mol Brain Res 15 62-66 Gao Z, Chen A, Barak D, Kim S, Muller C, Jacobson K (2002a) Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor. J Biol Chem 277 19056-19063... [Pg.160]

Mathew, J. Buchardt, O. Molecular imprinting approach for the recognition of adenine in aqueous medium and hydrolysis of adenosine 5 -triphosphate. Bioconjugate Chem. 1995, 6, 524-528. [Pg.219]


See other pages where Adenosine molecular recognition is mentioned: [Pg.161]    [Pg.143]    [Pg.153]    [Pg.297]    [Pg.52]    [Pg.5176]    [Pg.159]    [Pg.226]    [Pg.228]    [Pg.231]    [Pg.153]    [Pg.421]    [Pg.5175]    [Pg.332]    [Pg.427]    [Pg.560]    [Pg.138]    [Pg.216]    [Pg.166]    [Pg.525]    [Pg.2]    [Pg.155]    [Pg.620]    [Pg.420]    [Pg.203]    [Pg.9]    [Pg.31]    [Pg.159]    [Pg.328]    [Pg.31]    [Pg.158]    [Pg.159]    [Pg.24]    [Pg.80]    [Pg.101]    [Pg.237]    [Pg.230]    [Pg.172]    [Pg.2954]   
See also in sourсe #XX -- [ Pg.153 , Pg.154 , Pg.155 , Pg.156 , Pg.157 , Pg.158 , Pg.159 , Pg.160 , Pg.161 , Pg.162 ]




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Molecular recognition

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