Approaches to Molecular Imprinting

Dirion, and B. Sellergren Universitat Dortmund, Dortmund, Germany 

WHY DO WE NEED TO ADOPT A COMBINATORIAL APPROACH TO THE SYNTHESIS OF MIPs  

The fact that a large number of templates has been successfully imprinted using basic recipes has led to the proliferation of MIPs of relatively low complexity, most of which have been based on a restricted number of synthetic trials (even though in some cases supported by spectroscopic or computational hints). The majority of basic templates have been imprinted using methacrylic acid (MAA) as monomer (seeTable 5.6A in Ref. 1), the acidic ones using vinylpyridines (VPY) (seeTable 5.6B in Ref 1). Ethylene glycol dimethacrylate (EDMA) is the most used crosslinker (see Table 2.5 in Ref 1), acetonitrile, dichloromethane, chloroform, toluene the most used solvents. 

We distinguish between design and combinatorial approaches. In the former the area of host-guest chemistry has inspired the design of functional monomers 

The development and implementation of high-throughput screening techniques is expected to significantly accelerate the discovery of new, high-performance MIPS. 

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Sellergren B (2001) The non-covalent approach to molecular imprinting. In Sellergren B (ed) Molecularly imprinted polymers. Man made mimics of antibodies and their applications in analytical chemistry. Elsevier, Amsterdam... 

Fig. 1.8. The covalent approach to molecular imprinting in organic polymers, as introduced by the group of Wulff, exemplified by the o-glyceraldehyde MIP reported in 1972 [1],...

The non-covalent approach to molecular imprinting Choice of the liinctiona] monomer... 

The non-comlent approach to molecular imprinting TABLE 5.6C continued... 

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