Ferrocene monocarboxylic acid

PQQ-dependent glucose dehydrogenase, EC 1.1.99.17 50 mM glucose 0.05-2 mM ferrocene monocarboxylic acid, 0.05-2 mM ferrocene methanol, 0.05-2 mM p-amniophenol oxidation [35]... 

Figure 12. Voltammetric response of a GOx-SWCNT-modified glassy carbon electrode in the absence (red) and presence (blue) of 0.5 mM ferrocene monocarboxylic acid. The catalytic response (green) after the addition of 50 mM glucose is also shown. From reference 89.

Many derivatives have been prepared from ferrocene monocarboxylic acid (S). Acetylferrocene was reduced by lithium aluminum hydride to the carbinol, and this was then converted into vinylferrocene. From this, polymers and copolymers with other polymerizable substances have been obtained. The polymers are easily obtainable in the cationic form and in the reduced, uncharged form, which are interconvertible (5). Urethanes (3), amino acids and urea, hydantoin and pyrazoline derivatives with ferrocenyl substituents have also been prepared (100, 178). 

FIG. 15 Gold on silicon wafer completely coated with carbon spray. Tempered 6 hours at 453 K in air SECM image using a 10 jim Pt tip at a speed of 7 /xm/s in aq. 2 mM ferrocene monocarboxylic acid, 100 mM phosphate buffer at pH 7.2... 

Bartlett, P. N. Pratt, K. F. E. A study of the kinetics of the reaction between ferrocene monocarboxylic acid and glucose-oxidase using the rotating-disc electrode. J. Ekctroanal. Chem. 1995, 397, 53-60. 

Detailed studies of glucose oxidase immobilized in poly(N-methypyrrole) films using both ferrocene monocarboxylic acid and ferricyanide as the mediator species indicate that in both cases poly(N-methylpyrrole) films are insulating and there is no evidence of direct reoxidation of the mediator on the polymer. This is an unexpected result, since these mediators are electroactive at poly(N-methylpyrrole) films that do not contain GOx. It appears that in addition to catalyzing the oxidation of glucose in the presence of a mediator, GOx can also catalyze the reduction of oxygen to H2O2 in the presence of mediators (M) as electron acceptors... 

Cao s group in 2011 designed an ECL biosensor based on the construction of triplex DNA for the detection of adenosine which employs an aptamer as a molecular recognition element and quenches ECL of Ru(bpy)3 by ferrocene monocarboxylic acid (FcA) G ig. 6.5). In the presence of adenosine, the aptamer sequence (Ru-DNA-1) more likely forms the aptamer—adenosine complex with hairpin configuration and the switch of the DNA-1 occurs in conjunction with the... 

Figure 3, Cyclic voltammograms of 5 mM ferrocene monocarboxylic acid in 0.1 M phosphate buffer pH 7.1 on glucose oxidase encapsulated ormosil at 25 C and at the scan rate of3, 6,10, 20, 50 100 mV/s. The...

Horseradish peroxidase has also been used coimmobilized and coupled to a glassy-carbon electrode with ferrocene monocarboxylic acid as mediator dissolved in the carrier stream. Low detection limits were achieved in all cases using these systems, with some differences, although the selectivity was quite similar in the different assemblies (Tombelli and Mascini, 1998). Horseradish peroxidase has also been used by other authors (Lerke et al., 1983 Castilho et al., 2005). 

A mediator is a low-molecular-weight redox couple such as ferrocene monocarboxylic acid (Fecp2R ) that shuttles electrons from the redox centre of the enzyme to the surface of the sensing electrode. Thus polymerization of the pyrrole monomer in the presence of glucose oxidase... 

FIGURE 18.2 (a) Magnetic field-controlled reversible assembling of Au-coated magnetic nanoparticles and their use as a nanostructured electrode with the enhanced ability of electrochemical oxidation of ferrocene monocarboxylic acid coupled with glucose oxidation biocatalyzed by GOx. (b) CVs of ferrocene monocarboxylic acid (0.1 mM) obtained in the absence (i) and presence (ii) of the magnetic field. (Adapted with permission from Ref [63]. Copyright 2008, American Chemical Society.)... 

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