Ibuprofen Adefovir

Drugs that may interact with adefovir include ibuprofen. 

Adefovir is associated with a dose-dependent nephrotoxicity. The risk is low for treatment durations of up to 1 year at its recommended dosage for HBV but may rise in patients with preexisting renal dysfunction or in those treated for longer durations. Also, as with the antiretroviral nucleoside analogs (see Nucleoside Reverse Transcriptase Inhibitors), lactic acidosis and severe hepatomegaly with steatosis may occur. When coadministered with ibuprofen, the AUC of adefovir is increased by about 23%, apparently due to higher oral bioavailabilty. 

Oats Sitagliptin, cimetidine, ibuprofen, quinapril, indapamide, adefovir, cidofovir, tenofovir, cephalosporin, torsemide... 

The OAT proteins play a critical role in the excretion and detoxification of a wide variety of drugs, toxins, hormones and neurotransmitter metabolites. A number of common non-steroid anti-inflammatory drugs (NSAID), including acetyl salicylate and salicylate, acetaminophen, diclofenac, ibuprofen, ketoprofen, indomethacin, and naproxen, are substrates of one or more OAT isoforms, so that there can be significant interactions between NSAlDs and other drugs. The 3-lactam antibiotics (penicillins, cephalosporins and penems) and the antiviral nucleosides adefovir, cidofovir,... 

No clinically significant interaction appears to occur between adefovir and co-trimoxazole, didanosine, delavirdine, efavirenz, ibuprofen, indinavir, lamivudine, nelfinavir, nevirapine, paracetamol, tenofovir, or zidovudine. Adefovir possibly reduces saquinavir levels. 

Adefovir is excreted by the kidneys, by a combination of glomerular filtration and active secretion via the rend transporter, human Organic Anion Transporter 1 (hOATl). The potential for pharmacokinetic interactions with co-trimoxazole, ibuprofen, lamivudine, paracetamol and tenofovir (other drugs that also undergo, or may affect tubular secretion) has been investigated. ... 

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