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Addition hydroxylation

A significant fraction of the body s cholesterol is used to form bile acids Oxidation m the liver removes a portion of the CsHi7 side chain and additional hydroxyl groups are intro duced at various positions on the steroid nucleus Cholic acid is the most abundant of the bile acids In the form of certain amide derivatives called bile salts, of which sodium tau rocholate is one example bile acids act as emulsifying agents to aid the digestion of fats... [Pg.1097]

An alpha hydroxy acid is an organic carboxylic acid in which an additional hydroxyl functional group (-OH) is present at the alpha position, i.e., on the carbon adjacent to the carboxyl functionality, -COOH. Figure 13.10.1 presents the struc-... [Pg.183]

Further transformation included additional hydroxylation steps leading to 2,6-dihydroxyquinoline and a trihydroxyquinoline (probably 2,5,6-trihydroxyquinoline). Shukla [322], working with Pseudomonas sp. identified an alternate pathway, involving additional metabolites, besides the 2-hydroxyquinoline and 8-hydroxycoumarin. These were 2,8-dihydroxyquinoline and 2,3-dihydroxyphenylpropionic acid. Quinoline-adapted cells were also able to transform 2-hydroxyquinoline and 8-hydroxycoumarin without a lag phase, providing additional support for their intermediate role as intermediates in the metabolism of quinoline. [Pg.156]

Figure 14.14 Additional hydroxyl-particle activation methods include bis-epoxide modification, tosyl activation, and tresyl activation methods. The tosyl chloride and tresyl chloride activation procedures must be done in dry organic solvent, but the coupling of an amine-containing ligand can be done in either organic solvent or aqueous buffer. Figure 14.14 Additional hydroxyl-particle activation methods include bis-epoxide modification, tosyl activation, and tresyl activation methods. The tosyl chloride and tresyl chloride activation procedures must be done in dry organic solvent, but the coupling of an amine-containing ligand can be done in either organic solvent or aqueous buffer.
In the context of Lck SH2 domain ligands it was demonstrated that the introduction of an additional hydroxyl group onto the bridging methylene group, yielding the chmF 16 [4-(carboxyhydroxymethyl)phenylalanine] (Scheme 2), improved the potency threefold when compared to the corresponding cmF analogue [119]. [Pg.34]

An impressive list of degradative studies has been performed with Stauffer-s R-20458 including metabolism by eight insect species (15, 16), rats (15, 17), steers (18, 19), mice (20) and mammalian enzymes (15, 20, 21). It is evident that most published investigations have concentrated on metabolism by mammals and insects. Insect metabolism of R-20458 has been reviewed (22) and a summary of nonaquatic metabolism is given in Table V. Several additional hydroxylated metabolites were identified by Hoffman et al. (17) from rats. [Pg.165]

Fig. 23 Lactones formed by cyclization of an additional hydroxyl into an additional ester or acid... Fig. 23 Lactones formed by cyclization of an additional hydroxyl into an additional ester or acid...
In recent years, blown oils have found their way into the polyurethane industry. The additional hydroxyl content introduced through the oxidation process makes the oils more reactive toward isocyanates [82]. The oils can usually be incorporated at low levels into conventional formulations with little compromise to the mechanical properties of the finished polyurethanes. Blown oils have since found utility in carpet backing, insulation foams, and other polyurethane products [83]. At least a... [Pg.331]

Vitamin D is the collective term for a group of compounds formed by the action of ultraviolet irradiation on sterols. Cholecalciferol (vitamin D3) and calciferol (vitamin D2) are formed by irradiation of the provitamins 7-dehydrocholesterol and ergosterol, respectively. The conversion to vitamin D3 occurs in the skin. The liver is the principal storage site for vitamin D, and it is here that the vitamin is hydroxylated to form 25-hydroxyvitamin D. Additional hydroxylation to form 1,25-dihydroxyvita-min D occurs in the kidney in response to the need for calcium and phosphate. A discussion of the role of vitamin D in calcium homeostasis is provided in Chapter 66. [Pg.778]

The chair conformation of the six-membered ring in such compounds can be stabilized by hydrogen bonding by incorporation of an additional hydroxyl group, for example, compound 6 <2005JOC7107>. [Pg.494]

An alcohol may be acyclic or cyclic. It may contain a double bond, a halogen atom or additional hydroxyl groups. Alcohols are usually classified as primary (1°), secondary (2°) or tertiary (3°). When a hydroxyl group is linked directly to an aromatic ring, the compound is called a phenol (see Section 4.6.10), which differs distinctly from alcohols. [Pg.74]

In addition, hydroxyl polymers prepared by use of lithium alkyl acetal initiators have shown a high degree of functional purity (Table II). The functionality data for XI is a bit low, in part, because a linear GPC calibration was used to calculate nn (GPC). It should also be noted that Equations 1-9 proceed in the absence of anionic association or gel. [Pg.433]

Flavonols (about 380 aglycones) are characterized by the presence of a hydroxyl group at position 3, Fig. (4). About 90% of the flavonols have additional hydroxyl at positions 5 and 7. [Pg.264]

Another foreign body that typically interferes in eye bums is calcium oxide in any form like fluid concrete to fresh mixtures of CaO (Calcium oxide) with water. The reactive CaO dissolves with the water being attracted from the eye into Ca with additional hydroxyl ions. The saponification of the tissues by the alkali results in the diffusion of the foreign body into the tissue with deep comeal foreign body, difficult to remove [21]. All other known bioactive foreign bodies usually, more or less, follow these two different reaction types. [Pg.68]


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See also in sourсe #XX -- [ Pg.70 , Pg.88 ]




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Addition of hydroxyl compounds

Addition of hydroxyl radicals to double and triple bonds

Addition, conjugate hydroxylation

Cyclopentadiene, addition hydroxylation

Electrophilic addition hydroxylation

Hydroxyl addition reactions

Hydroxyl epoxide addition

Hydroxyl groups addition across double bonds

Hydroxyl radical addition

Hydroxyl radical electrophilic addition

Radical Hydroxylation (Addition-Elimination)

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