Adaptive immune system origins

The specific, or adaptive, immune system is characterized by memory, specificity, and the ability to distinguish self from nonself. The important cells of the adaptive immune system are the lymphocytes and antigen-presenting cells that are part of nonspecific immunity. The lymphocytes, which originate from pluripotent stem cells located in the hematopoietic tissues of the liver (fetal) and bone marrow, are composed of two general cell types T and B cells. The T cells differentiate in the thymus and are... 

One fairly new system is the Modular Immune in vitro Construct technology system (MIMIC), which can measure innate and adaptive immune responses and evaluate cytokines, antibodies, and chemokines in vitro. The system is based on a multidimensional interrogation of quiescent primary human cells mainly of blood origin that can reproduce immune responses in a cell-based high-throughput screen and rapidly capture the effect of an immunoresponsive agent (e.g.,... 

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