Acyl coenzyme dehydrogenase

FIGURE 24.11 The acyl-CoA dehydrogenase reaction. The two electrons removed in this oxidation reaction are delivered to the electron transport chain in the form of reduced coenzyme Q (UQH9). 

Step 1 of Figure 29.3 Introduction of a Double Bond The /3-oxidation pathway begins when a fait)7 acid forms a thioester with coenzyme A to give a fatty acyl Co A. Two hydrogen atoms are then removed from C2 and C3 of the fatty acyl CoA by one of a family of acyl-CoA dehydrogenases to yield an a,/3-unsaturated acyl CoA. This kind of oxidation—the introduction of a conjugated double bond into a carbonyl compound—occurs frequently jn biochemical pathways and usually involves the coenzyme flavin adenine dinucleotide (FAD). Reduced FADH2 is the by-product. 

The official name of this gene is "acyl-Coenzyme A dehydrogenase family, member 8."... 

For readers unfamihar with the Internet, detailed instructions are offered on how to access electronic resources. For readers unfamihar with medical terminology, a comprehensive glossary is provided. We hope these resources wih prove useful to the widest possible audience seeking information on medium-chain acyl-coenzyme A dehydrogenase deficiency. 

In this chapter, we wiU show you how to locate peer-reviewed references and studies on medium-chain acyl-coenzyme A dehydrogenase deficiency. For those interested in basic information about medium-chain acyl-coenzyme A dehydrogenase deficiency, we begin with a condition summary pubhshed by the National Library of Medicine. 

Genetics Home Reference (GHR) is the National Library of Medicine s Web site for consumer information about genetic conditions and the genes or chromosomes responsible for those conditions. Here you can find a condition summary on medium-chain acyl-coenzyme A dehydrogenase deficiency that describes the major features of the condition, provides information about the condition s genetic basis, and explains its pattern of inheritance. In addition, a summary of the gene or chromosome related to medium-chain acyl-coenzyme A dehydrogenase deficiency is provided. ... 

The Genetics Home Reference has recently published the following summary for medium-chain acyl-coenzyme A dehydrogenase deficiency ... 

What Is Medium-Chain Acyl-Coenzyme A Dehydrogenase Deficiency ... 

Worldwide, medium-chain acyl-coenzyme A dehydrogenase deficiency is estimated to affect 1 in 5,000 to 17,000 live births. In the United States, the estimated frequency of this disorder is 1 in 15,000 hve births. The condition is more common among individuals of northern European ancestry. 

To generate your own bibliography of studies dealing with medium-chain acyl-coenzyme A dehydrogenase defidency, simply go to the PubMed Web site at... 

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