Acute renal failure rifampicin

Covic A, Goldsmith DJ, Segah L, Stoicescu C, Lungu S, Volovat C, Covic M. Rifampicin-induced acute renal failure a series of 60 patients. Nephrol Dial Transplant 1998 13(4) 924-9. 

De Vriese AS, Robbrecht DL, Vanholder RC, Vogelaers DP, Lameire NH. Rifampicin-associated acute renal failure pathophysiologic, immunologic, and clinical features. Am J Kidney Dis 1998 31(1) 108-15. 

Diamond JR, Tahan SR. IgG-mediated intravascular hemolysis and nonoUguric acute renal failure complicating discontinuous rifampicin administration. Nephron 1984 38(l) 62-4. 

Kar HK, Roy RG. Reversible acute renal failure due to monthly administration of rifampicin in a leprosy patient. Indian J Lepr 1984 56(4) 835-9. 

Prakash J, Kumar NS, Saxena RK, Verma U. Acute renal failure complicating rifampicin therapy. J Assoc Physicians India 2001 49 877-80. 

Muthukumar T, Jayakumar M, Fernando EM, Muthusethupathi MA. Acute renal failure due to rifampicin a study of 25 patients. Am J Kidney Dis 2002 40(4) 690-6. 

Bassilios N, Vantelon C, Baumelou A, Deray G. Continuous rifampicin administration inducing acute renal failure. Nephrol Dial Transplant 2001 16(1) 190-1. 

Tubulointerstitial nephritis can be either acute or chronic in nature. Acute interstitial nephritis is characterized by an acute renal interstitial inflammatory response with urinary eosinophils and nonoliguric acute renal failure. The more common drugs that induce acute interstitial nephritis include penicillins, rifampicin, sulfonamides, and cimetadine. Chronic tubulointerstitial nephritis is most commonly associated with the long term use of large amounts of analgesics and antiinflammatory agents (e.g., NSAIDs). 

Penicillin-induced renal toxicity is most commonly seen as allergic acute interstitial nephritis (AIN). Methicillin is the most common penicillin to induce AIN, but the use of penicillin G, ampicillin, am-oxacillin, oxacillin, and carbenicillin also can lead to the development of AIN. Typically, acute renal failure follows 1 or 2 weeks of treatment with fever or rashes sometimes occurring before overt renal dysfunction. Removal of the penicillin generally allows renal function to return to normal within a few days or weeks. AIN can also be induced by certain cephalosporins (e.g., cephalothin, cephalexin, cephradine, cefoxitin, cefotaxime) and non-/i-lactam antimicrobials (e.g., sulfonamides, rifampicin, tetracyclines, erythromycin). 

Numerous case reports also describe this interaction ciclosporin levels or AUC have been increased by two- to threefold, " with changes being seen within 3 to 6 days of clarithromycin 250 or 500 mg twice daily being started. " Another patient had a seven- to twelvefold rise in serum ciclosporin levels and acute renal failure within 3 weeks of starting to take clarithromycin 1 g daily. Another case report in a heart transplant patient taking ciclosporin found that the addition of rifampicin to clarithromycin negated the increase in ciclosporin levels seen with clarithromycin alone, and the ciclosporin dose requirement with concurrent clarithromycin plus rifampicin was similar to that before clarithromycin or rifampicin were started. ... 

Calnan CD, Sarkany I (1958) Contact dermatitis from neomycin. Br J Dermatol 70 435-445 Campese VM, Marzullo F, Schena FP, Coratelli P (1973) Acute renal failure during intermittent rifampicin therapy. Nephron 10 256-260 Carpenter G (1975) Chloramphenicol eye-drops and marrow aplasia. Lancet 2 326-327... 

Kleinknecht D, Homberg JC, Decroix G (1972) Acute renal failure after rifampicin. Lancet 1 1238-1239... 

Manika K, Tasiopoulou K, Vlogiaris L, Lada M, Papaemmanouil S, Zarogoulidis K, et al. Rifampicin-associated acute renal failure and hemolysis a rather uncommon but severe complication. Ren Fail 2013 35(8) 1179-81. 

A number of reports have appeared on the adverse effects of rifampicin on the kidney. Courtois and de Coninck reported a case of acute renal failure requiring several transfusions and multiple periods of haemodialysis. Nephrotoxicity in this case developed when rifampicin was re-introduced into the treatment schedule after a gap of several weeks (25 ). A similar case was reported by Hanzl et at. from Germany (26 ) and a further case in which the nephrotoxicity became manifest during a course of twice weekly therapy was described by Nessi et al. (27 ). These authors also reviewed the cases reported to date in the literature, showing that interruptions of treatment or treatment on an intermittent basis are a common feature to most of the reported cases. Eventual renal failure may or may not be preceded by a flu-like illness. Renal biopsy has been carried out in approximately a third of the reported cases and a picture of tubular interstitial necrosis has been seen. The results of immunological tests have not been consistent, and antibodies to rifampicin have not been demonstrated in every case. It is perhaps worthy of note that renal failure has only, so far, been reported in patients who have had a fairly long course of treatment. 

Two examples of renal toxicity occurring in Chinese individuals were reported by Chan et al. (28 ). In both these patients antibodies to rifampicin were demonstrated and the histological picture from a renal biopsy was compatible with immunological damage to the kidney although no specific IgM could be demonstrated by immunofluorescence techniques. A brief Italian report (29 ) stated that in biopsies of patients with acute renal failure following rifampicin, evidence of an immunological... 

Courtois, R. and DeConinck, J. P. (1976) A new case of acute renal failure with high haemolysis after rifampicin. Acta tuberc. pneumol. beige, 66, 508. 

Filippo,G, (1976) Acute renal failure after rifampicin a case report and survey of the literature. 16, 148. 

Minetti, I,., Barbiano-Di-Bclgiojoso, G., Ci-vati, G., Durante, A., Scatizzi, A. and Surian, M. (1975) On the pathogenesis of acute renal failure due to rifampicin. (R-Arf) clinical and histological observations in four patients. Kidney Int., 8. 129. 

Tahan SR, Diamond JR, Blank JM, Horan RF. Acute hemolysis and renal failure with rifampicin-dependent antibodies after discontinuous administration. Transfusion 1985 25(2) 124-7. 

Mauri JM, Fort J, Bartolome J, Camps J, Capdevila L, Morlans M, Martin-Vega C, Piera L. Antirifampicin antibodies in acute rifampicin-associated renal failure. Nephron 1982 31(2) 177-9. 

Hemolytic anemia associated with rifampicin was hypothesized to be hapten mediated, as the patient s serum fixed complement in the presence of rifampicin. However, subsequent studies identified circulating erythrocyte-specific antibodies in the serum with specificity for both the Lutheran (Lu) and I antigens. The presence of the I antigen on the surface of leukocytes, platelets, and renal tubular epithelial cells may have accounted for the hemolysis, thrombocytopenia, and renal failure with acute tubular damage observed in the first patient. 

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