Acute neuroinflammation

Morimoto E., Murasugi T., and Oda T. (2002). Acute neuroinflammation exacerbates excitotoxicity in rat hippocampus in vivo. Exp. Neurol. 177 95-104. 

Table 8.3 Status of neuroinflammation, oxidative stress, and NF-/cB in acute neural trauma and neurodegenerative diseases...

Our emphasis on the interplay among excitotoxicity, oxidative stress, and neuroinflammation does not rule out the participation of other mechanisms involved in neural cell injury. However, it is timely and appropriate to apply the concept of interplay among excitotoxicity, oxidative stress, and neuroinflammation to neural cell injury in acute neural trauma and neurodegenerative diseases. Lack of coordination among the above parameters may control the time taken by neural cells to... 

Numerous biochemical markers of neuroinflammation have also been found in ALS tissue. The families of compounds include cytokines, chemokines, complement proteins, prostaglandins, interleukins, interferons, integrins, acute phase reactants, apolipoproteins, and (Table 27.1). Many of these biochemical markers have also been found in Alzheimer s disease tissues, suggesting that the inflammatory response in the two conditions may be similar (Eikelenboom and van Gool 2004). 

Williams AJ, Wei HH, Dave JR, Tortella FC (2007) Acute and delayed neuroinflam-matory response following experimental penetrating ballistic brain injury in the rat. J Neuroinflammation 4 17-19... 

---