Actonel

Risedronate (Actonel) 5 mg daily, 35 mg weekly, 75 mg on 2 consecutive days once monthly, 150 mg monthly ... 

Q62 Before the patient is started on Actonel, preventive dental treatment should be considered. Actonel is associated v/ith osteonecrosis of the jav/. 

Actonel contains risedronate sodium, a bisphosphonate. Osteonecrosis of the jaw has been reported in patients receiving oral bisphosphonates. Adequate oral hygiene should be maintained during and after treatment with bisphosphonates, including Actonel. Preventive dental treatment should be considered before starting bisphosphonates. Patient should be advised to maintain adequate oral hygiene during treatment. 

Multiple bisphosphonates compounds are available for both oral and intravenous use. Some [alendronate (Fosamax) and etidronate (Didronel)] are used for osteoporosis, others [etidronate, tirludronate (Skelid), risedronate Actonel) for Paget s disease, and yet others [pamidronate Aredia), zoledronic acid] for the hypercalcemia of malignancy. 

U.S. FDA (2006). Actonel. Actonel with Calcium. Available at http //www.fda.gov/ med watch / safety /2006/ Jan PI / Actonel Calcium PI.pdfit search=%22actonel%20calcium% 20risedronate%20usp%22 accessed 10/04/2006. 

Parenteral 2.5 mg per vial powder to reconstitute for injection Risedronate (Actonel)... 

It makes Allegra for allergies, Ambien for sleep problems, Plavix to prevent formation of blood clots that lead to heart attacks and strokes, Taxotere for treatment of breast cancer, Actonel for osteoporosis, Arava for rheumatoid arthritis symptoms such as joint swelling and tenderness, Lovenox for certain kinds of blood clots, Eligard for treatment of prostate cancer, and Lantus for diabetes. 

General Category Bisphosphonates Examples Alendronate (Fosamax) Etidronate (Didronel) Ibandronate (Boniva) Pamidronate (Aredia) Risedronate (Actonel) Treatment Rationale and Principal Indications Appear to block excessive bone resorption and formation is used to normalize bone turnover in conditions such as osteoporosis and Paget disease, and to prevent hypercalcemia resulting from excessive bone resorption in certain forms of cancer... 

Actonel [package insert]. Bridgewater, NJ Procter Gamble Pharmaceuticals, Inc 2006. 

Trade name Actonel (Procter Gamble) Indications Paget s disease of bone, postmenopausal osteoporosis... 

---