Activity introduction

C02 sequestration by mineral carbonation. (From Goldberg, P., Mineral Sequestration Team Activities, Introduction, Issues Plans, Powerpoint Presentation for Mineral Carbonation Workshop August 8, 2001 sponsored byNETL. http //www.netl.doe.gov/publications/proceedings/01/minecarb/goldberg.pdf, 2001. With permission.)... 

N-Alkylamino carbazoles (e.g., 494 and 495) possess significant anti-convulsant and diuretic activity. Introduction of an aminopropyl chain at the N-atom seems to enhance the anti-convulsant activity in combination with methoxy groups at positions 2, 3, and 4, or a chlorine atom at the C-2 and C-3 positions (458). 

Ligand-gated ion channels G protein-coupled receptors Receptors with intrinsic enzyme activity INTRODUCTION... 

The catalysts performance in MOIP dehydrogenation is given in Table 1. Alumina displayed significant activity with low selectivity to MA as a result of hi demetho lation activity. Introduction of copper increased the dehjnirogenation activity and MA selectivity of alumina while introduction of zinc led to low activity and complete selectivity to MA. The catalyst containii both metals on alumina yielded activity close to CU/AI2O3 but significantly... 

Ring substituents influence the activity. Unsubstituted phenoxyacetic acid has low activity. Introductions of halogens increase the activity in the following sequence 4 > 3 > 2. 

Further unsaturation of the B or C ring of 19-androstane derivatives usually enhances progestin activity. Introduction of a halogen or methyl substituent in the 6a or 7a positions generally increases hormonal activity. Acetylation of the 17p-OH of norethindrone increases the duration of action of the drug. Removal of the 3-keto function of norethindrone allows retention of potent progestin activity and no androgenic effects. 

Goldman AS, Goldberg K1 (2004) Organometallic C-H bond activation introduction. In Goldberg KI, Goldman AS (eds) Activation and Functionalization of C-H Bonds, ACS Symposium Series 885. American Chemical Society, Washington, DC, p 2... 

In contrast to aceclidine in which introduction of a methyl radical in position 6 of the quinuclidine ring [compound (LVI)] led to a sharp reduction in activity, introduction of the same radical in the same position of the oxylidine molecule had not appreciable effect on the activity. The hydrochloride of 6-methyl-3-benzoyloxyquinuclidine [compound LXIV)] did not differ significantly from oxylidine in its hypotensive, adrenolytic, anticholinergic or sedative activities. 

Position 3. Replacement of phenylalanine by tyrosine abolishes all activity. Introduction of an isoleucine residue gives vasotocin, a compound already described in the oxytocin series. 

In Table 11, the anti-HIV-1 activity of these Af-alkyl derivatives (122-124) is summarized together with that of the base 121 derived from HEPT. Although 121 and the N-methyl derivative 122 did not show any activity, introduction of an alkyl group longer than ethyl group to the N-1 position seems to contribute to the activity to some extent These results indicate that even the presence of an ether oxygen in the alkoxyalkyl structure is not essential for activity. 

Maytansinoids inhibit cilia regeneration in Tetrahymena pyriformis, and this activity is dependent upon the nature of the C(3)-acyl group (81). Introduction of a hydroxyl into this moiety markedly reduces activity. Introduction of a hydroxyl at C(15) or conversion of the C(14) methyl to a hydroxymethyl group will also lower activity. Loss of the epoxide group at C(4)-C(5) apparently does not affect activity. 

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