Active Heymann nephritis

Active Heymann nephritis (AHN), a model of human membranous nephropathy, induced in female Wistar rats by i.p. injection of proximal tubule brush border antigen (FxlA) brought about an increase of blood plasma TAC, beginning in week 9 and reaching maximum (134.9% of control) at week 15. After week 18, plasma TAC returned progressively to the control level (K14). 

K14. Koroliczuk, A., Chibowski, D., Beltowski, J., and Wojcicka, G., Selected markers of oxidative stress in rats with active Heymann nephritis. Med. Sci. Monit. 7, 369—376 (2001). 

Branisteanu, D.D. et al. (1993) Partial prevention of active Heymann nephritis by la,25-dihydroxyvitamin D3. Clinical and Experimental Immunology, 94, 412-417. 

Okubo et al. (1990) studied the immunosuppressive effects of FK506 on active Heymann s nephritis and the autologous phase of Masugi nephritis. 

Okubo Y, Tsukada Y, Maezawa A et al. (1990) FK506, a novel immunosuppressive agent, induces antigen-specific im-munotolerance in active Heymann s nephritis and in the autologous phase of Masugi nephritis. Clin Exp Immunol 82 450-455... 

The elevated urinary protein excretion and plasma creatinine due to the induction of Heymann nephritis were significantly reduced by fucoidan from L. japonica by oral intubation. This indicated that fucoidan has a renoprotective effect on active Heymaim nephritis and is a promising therapeutic agent for nephritis (Zhang et ah, 2005). 

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