Activator protein lung cancer

Brognard, J., Clark, A.S., Ni, Y., and Dennis. P.A. 2001. Akt/protein kinase b is constitutively active in nonsmall cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. 

Kim, Y., Chongviriyaphan, N., Liu, C., Russell, R.M., and Wang, X.D. 2006. Combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation increases the levels of lung retinoic acid and inhibits the activation of mitogen-activated protein kinase in the ferret lung cancer model. 

Berger W, Elbling L, Micksche M (2000) Expression of the major vault protein LRP in human non-small-cell lung cancer cells Activation by short-term exposure to antineoplastic drugs. Int J Cancer 88(2) 293-300. 

Mitogen-activated protein kinase kinase 1/2 Maximum tolerated dose Non-small cell lung cancer... 

Tsai CM, Chang KT, Wu LH, Chen JY, Gazdar AF, Mitsudomi T, Chen MH, Perng RP (1996) Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations, and cell proliferation characteristics in non-small cell lung cancer cell lines. Cancer Res 56 206-209 Oberall F, Oberhuber H, Maly K, Zaknun J, Demuth L, Grunicke HH (1991) Hexade-cylphosphocholine inhibits inositol phosphate formation and protein kinase C activity. Cancer Res 51 807-812... 

Witta SE, Gemmill RM, Hirsch FR et al. Restoring E-cadherin expression increases sensitivity to epidermal growth factor receptor inhibitors in lung cancer cell lines. Cancer Res 2006 66 944-950. Walker F, Kato A, Gonez LJ et al. Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation. Mol Cell Biol 1998 18 7192-7204. 

Ichiki K, Mitani N, Doki Y, Hara H, Misaki T, Saiki I. 2000. Regulation of activator protein-1 activity in the mediastinal lymph node metastasis of lung cancer. Clin Exp Metastasis 18 539-545. 

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