Activation of Cytokines and Chemokines in Spinal Cord Injury

6 Activation of Cytokines and Chemokines in Spinal Cord Injury 

In addition, SCI also induces the expression of chemokines, which are small structurally similar proteins released locally at the site of inflammation. They recruit immune cells and include MCP-1 and MIP-la. mRNA levels of IP-10 peak around 6 h post-injury and are upregulated up to 7 days post-injury. MCP-1 mRNA can be detected at 1 h post-injury and its levels returned to baseline by 14 days post-injury. An increase in MCP-1 staining is observed from 1 to 7 days post-injury (Lee et al., 

Infusion of the broad-spectmm chemokine receptor antagonist (vMIPII) in the contused spinal cord initially attenuates leukocyte infiltration, suppresses gli-otic reaction, and reduces neuronal damage after injury (Ghirnikar et al., 2000, 

7 Fas/CD95 Receptor-Ligand System in Spinal Cord Injury 

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