Activation Capability of Liver

As indicated in Section 1, one of the major considerations in regard to the usefulness of a test system in a battery of tests is its ability to provide metabolism of a type not performed by the other tests. Intact liver cells offer such an advantage in comparison to other test systems. 

Metabolizing systems for in vitro short-term tests are most frequently derived from rat liver, but other species deserve consideration. Significant differences exist in the hepatic metabolism of various rodent species. For example, guinea pig liver does not activate A -2-fluorenylacetamide. Aflatoxin Bi and 

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