Acridine dyestuffs

In other cases the activity ofthe drug is due to the ionized molecule. For example, with the antibacterial acridine dyestuffs it is the cation which is the active agent and factors favouring ionization, all other things being equal, enhance their antibacterial activity (see Chapter 12). 

Identification of dyes on dyed textiles is traditionally carried out by destructive techniques [493], TLC is an outstanding technique for identification of extracted dyestuffs and examination of inks. Figure 4.9 shows HPTLC/SERRS analysis of acridine orange [492], Wright et al. [494] have described a simple and rapid TLC-videodensitometric method for in situ quantification of lower halogenated subsidiary colours (LHSC) in multiple dye samples. The results obtained by this method were compared with those obtained by an indirect TLC-spectrophotometric method and those from HPLC. The total time for the TLC-videodensitometric assay of five standards and four samples applied to each plate was less than 45 min. The method is applicable for use in routine batch-certification analysis. Loger et al. [495,496] have chromatographed 19 basic dyes for PAN fibres on alumina on thin-layer with ethanol-water (5 2) and another 11 dyes on silica gel G with pyridine-water... 

Acridine C6H4CH-N-C6H4 (which is the starting compound for the synthesis of certain dyestuffs),... 

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