Acoustic Separation

The acoustic barrier particulate separator has been tested at the pilot-scale level. Pilot-scale tests were impaired because of a design problem in the acoustic separator. Funding cnts have prevented constmction and testing of a corrected design. This technology is not cnrrently commercially available. 

T. Lauiell, F. Petersson, and A. Nilsson, Chip integrated strategies for acoustic separation and manipulation of cells and particles. Chemical Society Reviews, vol. 36, no. 3, pp. 492-506, 2007. 

As the chip is actuated from underneath and an acoustic standing wave is induced in the flow channel since the excitation frequency is set to match the 1/2 resonance criterion of the channel width. It should be noted that the obtained standing wave in the flow channel is orthogonal to the incident wave propagation direction. This fact enables acoustic control of particle and cell displacement in the lateral direction, in plane with the microchip, which in turns opens the route to simple integration with other downstream acoustic separations steps or other microfluidic unit operations. 

FIGURE 44.9 Acoustic separation of lipid particles from blood at varying erythrocyte concentrations. Flow rate = 300 xL/min. (Reproduced from Petersson F., et al.. The Analyst, 129, 938-943, 2004. With permission from Royal Society of Chemistry.)... 

FIGURE 44.10 To increase the throughput of the acoustic separation device, eight parallel channels were connected in a bifurcation network. The image shows two eight channel separators on a 3" silicon wafer. 

Petersson F., Aberg L., and Laurell T., Acoustic separation of particles with similar acoustic properties by means of medium density manipulation, m Micro Total Analysis Systems, Proceedings of iTAS 2006 Conference. T. Kitamori, H. Fujita, and S. Hasabe (Eds.), Society for Chemistry and Micro-Nano Systems, Tokyo, Japan, 1052-1054, 2006. 

Acoustic separation Acoustophoresis Position manipiilaticHi of particles by ultrasonic fields Ultrasonic particle separation... 

Acoustic separation Acoustofluidics Acoustophoresis Ultrasonic concentration Ultrasonic particle manipulation Ultrasonic separation... 

FIGURE 7B.11 Principle of acoustic separation and stages of cell aggregation leading to particle settling. (Reproduced from Hill and Harris (2007) with kind permission from Springer Science + Business Media LLC, New York, USA. 2007.)... 

FIGURE 7B.12 Schematic of bioreactor using an acoustic separation device. (Reproduced from USER MANUAL BioSep ADH015 September 2001 with permission from Applikon Biotechnology B.V. 2001.)... 

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