Acids, Cu complexes

Investigation of Fulvic Acid—Cu Complexation by Ion-Pair Reversed-Phase High-Performance Liquid Chromatography with Post-Column Fluorescence Quenching Titration... 

BUTLER RYAN Investigation of Fulvic Acid—Cu Complexation... 

However, in 1950 Hangarter had begun his research with his newly developed salicylic acid Cu complex (Permalon, SACC). The structure(s) of the Cu complex(es) of salicylic acid in SACC are not known with certainty but 2... 

In an effort to correlate all of these experimental observations, it is suggested that one of the tissue factors responsible for irritant-induced anti-inflammatory activity may be the increase in serum ceruloplasmin as well as in albumin and amino acid Cu complexes. These are known to increase in serum of man and animals in response to irritants [6,7,66],inflammation [23.6—8,84], and infection [2,3,66,85] as a primary response to the etiological agents. The increase of these acute phase reactants in serum is consistent with the observations that inorganic Cu and Cu complexes have anti-inflammatory activity when tissue distribution is assured by parenteral administration and with the idea that this activity is physiological in nature. This aspect of the anti-inflammatory activity of Cu complexes is considered in greater detail (see page 213). 

Recently, Hiersemann reported the first catalytic enantioselective Claisen rearrangement (Scheme 2.4) [11]. The 2-alkoxycarbonyl-substituted allyl vinyl ethers 11 are reactive under the Lewis acid catalysis. Therefore, the Claisen rearrangements proceed catalytically [12]. Usually the Lewis-acid-catalyzed Claisen rearrangement does not proceed catalytically because of a higher affinity of the carbonyl product for the Lewis acids than the ether substrate. But this 2-alkoxycarbo-nyl-substituted substrate 11 can coordinate to metals in a bidentate fashion. This 2-alkoxycarbonyl substrate has higher affinity for Lewis acidic Cu complexes than the simple ether substrate. In this system, chiral copper (II) bisoxazoline Cu (box) complex 13 is effective for the enantioselective Claisen rearrangement. 

New chelating ion-exchange resins are able to selectively remove many heavy metals in the presence of high concentrations of univalent and divalent cations such as sodium and calcium. The heavy metals are held as weaMy acidic chelating complexes. The order of selectivity is Cu > Ni > Zn > Co > Cd > Fe + > Mn > Ca. This process is suitable for end-of-pipe polishing and for metal concentration and recovery. 

Two mechanisms are possible for the Cu-mediated aziridination using PhI=NTs as a nitrogen source (i) aziridination via Cu-nitrenoid species (L Cu=NTs) and (ii) aziridination via a L (Cu—PhI=NTs) adduct, in which the Cu complex functions as a Lewis acid catalyst. Jacobsen et al. demonstrated that the enantioselectivity of the aziridination using (48) as the chiral auxiliary did not depend on the nitrogen precursors.1 5 This supports the intermediacy of the Cu-nitrenoid... 

Mixed-ligand Cu(II) complexes with salicylato and phenanthroline derivatives as ligands can also be highly cytotoxic (231). Mixed-ligand Cu(II) amino acid phenanthroline complexes (Casiopeinas) such as [Cu(L-Ser)(phen)(H20)]+ 52 are reported to be effective anticancer agents (232). It is possible that a complex in this class will soon enter clinical trials. 

TABLE 7.4 Influence of ct-Amino Acid Ligands on the Equilibrium Constant for Binding of 3.8c to the Ligand-Cu Complex (K ) and the Second-Order rate Constant (fccat) for Reaction of this Ternary Complex with Diene 2 and the Enantioselectivity of this Reaction in Water ... 

Cu" complexes of 3,6-dioxaoctane-l,8-diamine-NNN N -tetra-acetic acid CU3MX4 (M = V. Nb, or Ta ... 

---