Acidic raising

Add, with stirring, a solution of 6 8 g. of the fiis-diazo ketone in 100 ml. of warm dioxan to a suspension of 7 0 g. of freshly precipitated silver oxide in 250 ml. of water containing 11 g. of sodium thiosulphate at 75°. A brisk evolution of nitrogen occurs after 1 5 hours at 75°, filter the liquid from the black silver residue. Acidify the almost colourless filtrate with nitric acid and extract the gelatinous precipitate with ether. Evaporate the dried ethereal extract the residue of crude decane-1 10-dicarboxylic acid weighs 4 -5 g. and melts at 116-117°. RecrystaUisation from 20 per cent, aqueous acetic acid raises the m.p. to 127-128°. 

Hydrogen bonding m carboxylic acids raises their melting points and boiling points above those of comparably constituted alkanes alcohols aldehydes and ketones... 

Polylactates are an interesting class of biodegradable polymers which may be made from either renewable or petroleum feedstocks. The synthesis of lactic acid raises real issues concerning the relative greenness of the renewable and non-renewable (HCN) route as discussed in Chapter 2. A summary comparison of the greenness of both routes is shown is Table 6.4. Without a full LCA the choice of route on environmental grounds is not easy and at least partly depends on plant location and raw material availability. 

Solution of the oxalic acid causes a sharp drop in temperature whereas solution of the sulfuric acid raises the temperature. 

In addition, a high intracellular concentration of fatty acids raises that of long-chain acyl-CoA, which can damage... 

Medard Thomas (Ref 20) reported that on nitration of technical DPE previously purified with acetone, they obed DPEHN of mp 68.3°. Treatment of this product with 79% nitric acid raised the mp to 73.7°, but they were not able to prep the compound with mp 75° as was reported by Friederich von Brim (Ref 3)... 

Tellurium dioxide is very sparingly soluble in water (1 part in 150,000 at the ordinary temperature). The solution has no acidic properties. The presence of even small quantities of nitric acid raises the solubility, on account of the formation of a basic nitrate, hot dilute solutions of which, however, frequently deposit the dioxide in a crystalline form on cooling.6 It is also soluble in diluted sulphuric acid, owing to the formation of basic telluric sulphate.7... 

Proton loss Hydroxy Acidity raised 3.2.3.7.1 Carboxylic acid... 

E. Bouty found that nitrates dissolved in cone, nitric acid raise the conductivity in proportion to the amount dissolved. A. Klemenc and R. Scholler measured the conductivity of mixtures of nitrous and nitric acids, but obtained no definite evidence of the existence of H2N308. Observations on the temp, coeff. were made by P. Kohlrausch and O. Grotrian, C. Deguisne, and J. and G. E. Gibson. According to S. Arrhenius, the temp, coeff. between 18° and 52°, is ... 

Au°/AuI ratio decreased as the carbon monoxide pressure increased,103 the rate being maximum when this ratio was about unity. In line with this, modification of Au/MgO by ascorbic acid raised the activity, possibly because it favourably alters the Au2+/Au° ratio.109 Iron and manganese also act as promoters, perhaps by forming Mn+-Au° (M = Fe, Mn) ensembles on magnesia.110... 

When an alkaline oxide such as MgO is stirred in phosphoric acid, the pH of the solution rises slowly due to the neutralization of this acid. Initially, the phosphoric acid has pH 0, but initial dissolution of the oxide and reaction with phosphate anions precipitate phosphate salts. This neutralization of the acid raises the pH of the solution to >2. Even in this pH range, the acid dissolves sufficiently, and protons and H2PO4 anions are readily available to react with the ions produced by the dissolution of metal oxides. Subsequently, consolidation of the precipitate in the neutral solution leads to the formation of ceramics. 

Appreciable research on the effect of canola oil on plasma cholesterol and lipoproteins has been reported. The primary impetus for this research was the finding that dietary monounsaturated fatty acids were as effective as polyunsaturated fatty acids in lowering plasma total and LDL cholesterol (100, 109). These findings also provided a possible explanation for the observation that canola oil was as effective as soybean oil in lowering plasma cholesterol in normolipidemic men (110). Prevailing theory had held that saturated fatty acids raised plasma cholesterol, polyunsaturated fatty acids lowered plasma cholesterol, and monounsaturated fatty acids were neutral, they neither raised nor lowered plasma cholesterol (111, 112). 

Systemic or topical antimicrobial therapy (tetracycline, minocycline, erythromycin, at low dose) is used over months (response begins after 2 months). Bacterial resistance is not a problem benefit is due to suppression of bacterial lipolysis of sebum, which generates inflammatory fatty acids. Raised intracranial pressure with loss of vision has occurred with tetracycline used thus. 

---