Achiral stationary phase functional groups

The packing materials described above separate chemical entities by exploiting chemical differences, e.g., hydrophobicity. Another class of stationary phases separates molecules based on chirality this is accomplished using a silica particle derivatized with a chiral moiety. There are several classes of chiral stationary phases including helical polymers, brushlike functional groups, protein/peptides, and inclusion complexes. Each of these is described in more detail below. Some manufacturers produce chiral stationary phases that operate either in reversed-phase or normal-phase mode, and some chiral stationary phases can be used in both modes. As with other stationary phases, there are numerous manufacturers of chiral stationary phases. However, contrary to Cl 8 and other achiral packing materials, each manufacturer of chiral stationary phases typically offers unique phases with completely separate selectivities. 

Do the products have a functional group available for derivatization by a chiral or achiral reagent, or for interaction with a stationary phase in chromatography or with a chiral agent in solution ... 

In the last 30 years, the so-called chiral chromatographies have been a cornerstone in the tremendous developments of all the aspects of chiros-ciences. Three techniques have been developed for the analysis of enantiomers (a) liquid chromatography on chiral support and elution with an achiral solvent that comprises also supercritical COz (b) gas chromatography on a chiral stationary phase (CSP), and (c) liquid chromatography on an achiral support with a chiral additive in the mobile phase. The resolution of atropisomers that do not presents suitable functional group for classical resolution by formation of diastereomers with optically pure amines or acids became reachable. 

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