4- Acetyl-5-hydroxy-2-methyl

Fig. 11 Natural rubber is produced from a side branch of the ubiquitous isoprenoid pathway, with 3-hydroxy-methyl-glutaryl-CoA (HMG-CoA) as the key intermediate derived from acetyl-CoA by the general mevalonic-acid pathway. Mevalonate diphosphate decarboxylase (MPP-D) produces IPP, which is isomeiized to DMAPP by IPP isomerase (IPI). IPP is then condensed in several steps with DMAPP to produce GPP, FPP and GGPP by the action of a trani-prenyltransferase (TPT). The cA-l,4-polymeiization that yields natural rubber is catalyzed by cA-prenyltransferase (CPT), which uses the non-allylic IPP as substrate. Reprinted from [248], with permission from Elsevier...

Acetyl-1,6-diisopropyl-4,7-dimethyl-1, 6-naphthyridine-2,5(l//,6/f)-dione 8-Acetyl-7-(2-dimethylaminovinyl)-6-propyl-1, 6-naphthyridin-5 (6/7)-one 3-Acetyl-4,7-dimethyl-1,6-dipropyl-1, 6-naphthyridine-2,5(l//,6/f)-dione 3-Acetyl-7-ethyl-4,8-dimethyl- 1,6-dipropyl-1, 6-naphthyridine-2,5(l//,6/f)-dione 3-Acetyl-4-hydroxy-1,6,7-trimethyl-1, 6-naphthyridine-2,5(l//,6/f)-dione 3-Acetyl-2-methyl-1,6-naphthyridine 8-Acetyl-7-methyl-1,6-naphthyridin-5(6H)-one... 

Physiologically active phosphates and thionophosphates have been obtained from 3-hydroxy-81 and 5-hydroxy-82 indoxazenes. 6-Hydroxy compounds are known they can be acetylated and methylated in the usual ways.39... 

Disposition in the Body. Rapidly absorbed after oral administration but extensively metabolised. A considerable number of metabolites have been identified in small quantities in urine. Less than 5% of a dose is excreted unchanged in the urine, and up to about 14% is excreted as 4-methylthiazole-5-acetic acid. Other metabolites identified in the urine include 5-(l-hydroxy-2-chloroethyl)-4-methylthiazole and 5-(2-hydroxyethyl)thiazole-4-carbolactone (which appear to be more abundant than 4-methylthiazole-5-acetic acid), together with 5-acetyl-4-methyl-thiazole, 5-(l-hydroxyethyl)-4-methylthiazole, and 5-(2-hydroxy-ethyl)-4-methylthiazole in both free and conjugated forms. 5-Ethyl-2-hydroxy-4-methylthiazole has been found in the tissues following overdoses of chlormethiazole. 5-(l-Hydroxyethyl)-4-methylthiazole and 5-acetyl-4-methylthiazole may be present in the plasma at concentrations similar to, or greater than those of unchanged drug. 

Amin Acetyl-(butyloxy-methyl)-methyl- IV/lb, 1024 Aminoxid (R)-Dimelhy -(cis trans-2-hydroxy-cyclohexyl)- E16a, 415 (Amin-Oxidat.)... 

Acetyl-phenyl)-3-hydroxy-methyl-3-methyl- Elba, 1203 (Ar-Nf + Amin) l-(2-E(hoxycarbonyl-phenyl)-3-methyl- EI6a, 1187(Ar-N + Amin)... 

Oxiran 2-Acetyl-2-(cyclohexyl-hydroxy-methyl- E21c, 4657 (En-Oxigenier.)... 

Acetyl-7-methyl- Vll/2a, 316f. 6-Propanoyl- VII/2a, 316f. Tricyclo 5.5.1.0 1 J trideca-113,2,4-trien 7-Hydroxy- E17f, 638 (1-R — 2-cycl.-acyl—aren/hv)... 

SYNS 2-ACETYL-5-HYDROXY-3-OXO-4-HEXENOIC ACID A-LACTONE 3-ACETYL-6-METHYL-2.4-PYRANDIONE 3-ACETYL-6-METHYLPYRANDIONE-2,4 3-ACETYL-6-METHYL-2H-PYRAN-2,4(3H)-DIONE DEHYDRACETIC ACID DEHYDROACETIC ACID (FCC) DHA DHS... 

Allyliden-l-ethenyl- 2233, 2234 7- [Benzyl-(2,2-diphenyl-acetyl)-amino]-methyl -4-hydroxy- 1742... 

Both 10-hydroxy- (20) and lO-methoxycanthin-6-one (21) have been isolated from the wood of 5. multiflora (42), and 20 has also been isolated from the root of Eurycoma longifolia (43). The UV spectrum of 20 shows a large bathochromic shift (76 nm) on alkali addition. Both the UV and IR spectra of 20 resemble those of 18. Acetylation and methylation of 20 produce the monoacetate and monomethyl ether, respectively. In the H-NMR spectrum of 20, two isolated pairs of vicinal protons in rings C and D and 1, 2, 4-trisubstituted aromatic protons are observed. From these observations Arisawa et al. (42) concluded that the hydroxyl function should associate with position 9 or 10. The position was fixed by the interlocking evidence, and structure 20 was determined. There was an increase in the molecular ion of 14 mass units in the mass spectrum of 21 as compared to 20 and the appearance of a new signal (8 3.91, 3H, s)... 

With the inhibitory activity against cyclic adenosine monophosphate phosphodiesterase as an index, in vitro bioassay of the activity of 21 canthin-6-one alkaloids was carried out. The strongest inhibitory activities were detected with 4, 17, and 27 among the compounds tested. The activities shown by 10, 28, and 34 were the same, twice as strong, and 15 times as strong, respectively, as the activity of papaverine, the control. Acetylation and methylation of the hydroxy derivatives of canthin-6-one decreased activity (108,109). 

Acetyl-5-hydroxy-3-mcthyl-l-phenyl- 527, 627 4-Acetyl-5-hydroxy-3-nitro-l-(4-nitro-phenyl)- 515 4-Acetyl-5-mercapto- 661 3-Acetyl-l -mcthoxycarbonyl-5-methyl- 509 3-Acetyl-l-methyl- 656... 

Acetyl- 816, 832 l-Acctyl-3-hydroxy- 835. 851 l-Acetyl-7-methyl- 833 1-Acetyl-5-nitro- 833 1-Acyl- 832, 839, 850... 

Athyl-benzoyl-amino)-l-liydroxy- 646 2-Xthyl-1 - [hutadicn-( 1,2)-yl J- 270 Amino- 570,1047, 1072, 1120. 1127, 1460, 1464, 1578 2-Atnino-l-acetyl- 993. 1100, 1268, 1312 4-Amino-1-acetyl- 993 2-(2-Amino anilino)-l.3.4-lrimelhyl- 1268 4-Ainino-l,3-dimethoxy- 994 2-Amino-3.5-dimethoxy-l -acetyl- 994 6-Amino-l.5-dimethyl- 1334 2-Amino-5-hydroxy-1 -acetyl- 567. 1269 2 mino-5-hydroxy-l,3-di-tert.-butyl- 1336 2-Amino-5-hydroxy-6-mcthyl-l-acetyl- 567 6-Amino-3-hydroxy methyl-1-acetyl- 567 6-Amino-3-hydro. y-2-mcthyl-l -acetyl- 567 6-Amino-5-[2-hydroxy-propvl-(2)]-l,3-di-lerl.-butvl-1342... 

---