Acetoacetyl chloride

In the presence of strong acid, such as boron trifluoride [7637-07-2] appropriately substituted acyl chlorides (7, R = CCl ) add to ketene to form the corresponding acetoacetyl chlorides, which can further react with alcohols to form the corresponding acetoacetates. 

QHiqO 141-97-9) see Aminophenazone Baclofen Cefotaxime Ceftazidime Chloroquine Cloricromen Cloxacillin Dipyridamole Felodipine Flutoprazepam Hymecromone Kawain Lacidipine Leflunomide Methylthiouracil Nevirapine Nitrendipine Oxacillin Pentoxifylline Propyphenazone Sulfamerazine acetoacetic acid 4-(trifluoromethyl)anilide (C H (,F3N02 351-87-1) see Leflunomide acetoacetyl chloride... 

The procedure described is related to that for preparing acetoacetyl chloride from diketene and hydrogen chloride.1 2 3... 

Unlike acetoacetyl chloride, which decomposes at temperatures above —20°, 2,2,4-trimethyl-3-oxovaleryl chloride is stable at elevated temperatures. It may find use as an intermediate for example, it can be used in the preparation of acid chlorides by an exchange reaction which is forced to completion by decarboxylation of the by-product, /3-keto acid ... 

When the /S-lactone of S-hydroxy-3-butenoio arid is treated with dty hydioohliaio arid at - 7 and then at —60", acetoacetyl chloride is fonned this compound, which i an aoetoacetylating agent, decom-poBC above —20" to d ydioacetio arid.s . The aame reaction occur with hydrolwomic arid s , w... 

Indane-l,3-diones 44 can be synthesized by a three-component sequential aluminum-chloride-promoted cross condensation-cycloacylation of various acyl chlorides (Scheme 2.20). Thus, the poorly stable acetoacetyl chloride 41, produced in situ by aluminum chloride-promoted self-condensation of acetyl chloride, reacts at the methylene active carbon with aromatic acyl chlorides 42, giving the reactive complexes 43 that... 

The principal reaction products were found to be pentachloro-acetoacetyl chloride, tetrachlorosuccinyl, dichloromaleyl, and dichloro-malonyl chlorides together with trichloroacetyl chloride, carbon tetrachloride, and phosgene. An induction period was observed, which could be reduced by irradiation with UV light, and the subsequent oxidation rate was independent of the concentration of the diene but dependent on the first power of the dissolved oxygen concentration. 

The aldol-like self-condensation of acetyl chloride in the presence of AICI3 gives the Al-chelate of acetoacetyl chloride (467). Reaction of this with thiophene-2-carboxylic acid chloride gives (469) in 72% yield via (468) <92JCS(Pl)2985>. Use of malonyl chloride instead of acetylchloride gives (471) (78%) via (470). 

See also Acetoacetyl-CoA in citric acid cycle, 6 633 Acetyl cyclohexanesulfonyl peroxide (ACSP), 74 282 78 478 Acetylene(s), 7 177-227, 227-228 25 633 addition of hydrogen chloride to, 73 821 from calcium carbide, 4 532, 548 carbometalation of, 25 117 as catalyst poison, 5 257t chemicals derived from, 7 227-265 decomposition of, 70 614 Diels-Alder adduct from cyclopentadiene, 8 222t direct polymerization, 7 514 economic aspects of, 7 216-217 explosive behavior of, 7 181-187 as fuel, 7 221-222 health and safety factors related to, 7 219... 

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