Acetamide fluoro

Deoxy-3-[ F]fluoro-D-glucose ( F-3DFG) was prepared - 454,467,473-476 essentially according to the procedure for the cold synthesis (see Section 11,2), namely, treatment of248 with Cs F (in DMF or HMPA), tetraalkylammonium [ F]fluoride (DMF, HMPA, or MeCN) or K F (in acetamide). 6-Deoxy-6-[ F]fluoro-a-D-galactopyranose was likewise pre-pared aceording to the cold synthesis. ... 

By reactions similar to the above we also prepared NN-di-(2 hydroxyethyl)fluoroacetamide and NN-di - (2 chloroethyl)fluoro -acetamide. 

B. Kuhnast, B. Lagnel - de Bruin, F. Hinnen, B. Tavitian, F. Dolle, Design and synthesis of a new [ F]fluoropyridine-based haloacetamide reagent for the labeling of oligonucleotides 2-Bromo-N-[3-(2-[ F]fluoro-pyridin-3-yloxy)-propyl]-acetamide, Bio-conj. Chem. 15 (2004) 617-627. 

M.-R. Zhang, J. Maeda, M. Ogawa, J. Noguchi, T. Ito, Y. Yoshida, T. Okauchi, S. Obayashi, T. Suhara, K. Suzuki, Development of a new radioligand, A/-(5-fluoro-2-phenoxyphenyl)-A/-(2[ F]fluoroethyl-5-methoxybenzyl)acetamide, for PET imaging of peripheral benzodiazepine receptor in primate brain, J. Med. Chem. 47 (2004) 2228-2235. 

Perfluoro[AT-fluoro-Af-(4-pyridyl)acetamide], prepared via direct fluorination of the sodium salt of perfluoro[/V-(4-pyridyl)acetamide], readily fluorinates diethyl sodio(phenyl)malonate, 1-morpholinocyclohexene, phenol and anisole under mild conditions.129... 

Acetamide N-(2-Chloro-ethyl)-fluoro- E10b2. 334 (Educt) C4H7aFN03S... 

Acetamide N.N-Dimethyl- 2-fluoro-2-phCiiyl- ElOa. 272 (En — OSiRj + F3C-OF) EJOb,. 8 (En- 1-NR,-... 

Both lyotropic and thermotropic liquid-crystalline synthetic polymers have been widely studied. Aromatic polyamides constitute the most important class forming liquid-crystalline solutions the solvents are either powerfully protonating acids such as 100% sulphuric acid, chloro-, fluoro- or methane-sulphonic acid, and anhydrous hydrogen fluoride, or aprotic dipolar solvents such as dimethyl acetamide containing a small percentage, usually 2-5 %, of a salt such as lithium chloride or calcium chloride. Such solutions constitute a nematic phase within certain limits. Some criteria for formation of a nematic instead of an isotropic phase are ... 

DFIT-induced fluoro-Pummerer reactions of N-substituted-2-(phenylsul-fanyl)acetamides have also been reported (Scheme 37) [107]. With some amides, cyclization of the Pummerer intermediate was competitive with fluorination, and in other cases, fluorination was preempted by sulfoxide formation. 

Chemical Name Acetamide, N-(((5S)-3-(3-fluoro-4-(4-morpholinyl)phenyl)-2-oxo-5-oxazolidinyl)methyl)-... 

R)-cis]-N-[3-[3-Fluoro-(tetrahydro-l-oxide-2H-thiopyran-4yl)phenyl-2-oxo-5-oxazolidinyl]methyl]-acetamide... 

Acetylcarbromal (slow), bromvaletone, carbromal, chloramphenicol, dinitolmide, etenzamide (weak), ethionamide, fluoro-acetamide, nicotinamide, phenacemide (slow), pheneturide (slow), prothion-amide, pyrazinamide, salicylamide (weak), urea... 

Y- 2-(4-fluoro-l//-imidazol-5-yl)ettiyl]acetamide (a-jV-Acetyl-4-fluorohistamine, 23) Typical Procedure for One-Pot Nitro Reduction, Diazotization, and Photochemical Fluorodediazoniation 65... 

C5H9F 1-fluoro-2-methyl-cis-2-butene 66213-76-1 317.11 26.763 2 5218 C5H9N02 N-acetyl-N-methyl acetamide 1113-68-4 468.15 40.833 1,2... 

By comparison of the calculated electrostatic potentials (77) of trans-2-butene and 2-fluoro-2(Z)-butene with N-methyl acetamide as simple models of the peptidic bond and its isosteres (see figure 1) the fluoroolefin clearly is the better replacement of the amide bond, since it not only mimics its steric but also, at least in part, its electronic feature. Calculating dipole moments Abraham (73) came to similar results, but attempts to synthesize the corresponding dipeptide isostere 2 have been until now unsuccesful (14). As part of our ongoing program in fluoroorganic chemistry we developed two general methods for the preparation of these compounds. 

Figure 1. Dreiding and CPK representation (standard geometries) and electrostatic potential profiles of N-methyl acetamide, trans-2-butene and 2-fluoro-2(Z)-butene...

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