Acetal, III

Figure 12. Synthesis of chrysene 1,2-dihydrodiol by Method IV (52). Reagents (i) H (ii) isopropenyl acetate (iii) DDQ (iv) (KS03)2N0 (v) NaBH4,02.

Both the nitrosoenamine II and the nitrosamino acetate III demonstrated some unusual chemistry which led us to the study of nitrosamine fragmentation reactions which will be discussed below. Treatment of the nitrosoenamine II with dilute sulfuric acid led to the formation of benzyl phenyl ketone as anticipated, but the major product from this reaction was benzoin, as is illustrated in equation 2 (3). While this transformation and the proper-... 

Chidgey. M.A.J.. Kennedy, J.F. Caldwell. J. (1987) Studies on benzyl acetate. III. The percutaneous absorption and disposition of [zzzct/zy/ez7e-> iC]benzyl acetate in the rat. Food chem. Toxicol.. 25. 521-525... 

It has been reported that the product distributions change with added acetate in both the chloride containing (10) and chloride free media (10, 11, 12) In one report (12) in the absence of added acetate the product consisted of 96% isopropenyl acetate, III. At [NaOAc] = 0.88 molar, III made up only 10% of the product, the other 90% being the allyl acetate, V. 

Kabadi, M. Chien, Y. Intravaginal controlled administration of flurogestone acetate III. Drug Dev. Ind. Pharm. 1985,11, 1271-1312. 

Fang JY, Fang CL, Huang YB. Transdermal iontopheresis of sodium nonivaride acetate III combined effect of pretreatment by penetration enhancers. Int ] Pharm 1997 149 183-195. 

Mit dieser Sequenz von Claisen/Cope-Umlagerungen kann man z.B. aus dem Acetal III Citral (3,5-Dimethyl-2,6-octadienal) in 70—80°/oiger Ausbeute herstellen15 ... 

Bis-(2,2-dipyridyl)-silver(II) peroxydisulfate, Ag(dipy)2SjOg. Mol. wt. 684.44. The reagent is prepared in the same way as the corresponding pyridine complex. Oxidative acetoxylation of arenes. This Ag(II) salt oxidizes arenes in acetic iii lcl containing sodium acetate to acetoxyarenes usually in high yield. The... 

In Eqn. (c) compound (II) is treated with p-chloro-benzoyl chloride in the presence of diy dimethyl formamide and sodium hydride when the corresponding n-substituted ester i.e., terCbutyl-l-p-chlorobenzoyl-2-methyl-5-methoxy-3-indolyl-acetate (III) is formed with the elimination of one mole of HCl. 

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