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Benzoyl chloride 0-chloro

However, in the presence of chlorendic anhydride, the decomposition of diethoxyacetophenone occurs only by Norrish I type cleavage, yielding benzoyl chloride, acetophenone and benzll. No Norrish Type II cleavage products were observed. The 24 hour photolysis of chlorendic anhydride in acetone using diethoxyacetophenone as the photoinitiator shows carbon-chlorine homolytic bond cleavage and the generation of chlorendic radicals as evidenced by the appearance of benzoyl chloride, chloro-... [Pg.212]

N-(4 Methoxyphenyl)-N-benzoyl-3-chloro-3-chloroantranlllc acid (4) 2 To ice cooled NaoEt (Irom 0 11 g Na and 10 mL ElOH) was added in rapid succession meltiyl 2 chloro 6 hydroxybenzoate 2 (0 86 g 4 7 mmol) and N (4 methoxyphenyl)benzimidyl chloride 1 (t 14 g 4 7 mmol) in EI2O (30 mL) The mixture was stirred vigorously and allowed to stand at rt tor 48 h The oily solid obtained alter evaporation was heated to 210 215°C lor 70 min under N2 The product was diluted with water (5 4 mL) ElOH (10 8 mL) and treated with 1 M NaOEt (5 4 mL) The mixture was relluxed lor 90 mm the solvent evaporated and the aqueous solution acldilied The dark oil was heated with NaOH (7 5 g) m EtOH (22 mL) Alter removal ol benzoic acid by exhaustive extraction with water the product was recrystallized Irom EtOH to give 0 36 g ol 4 (27 7%), mp 139 5 140 5°C... [Pg.61]

A somewhat different strategy is employed for preparation of the desoxy analogue containing the reversed pyrazole. Acylation of chloropyrazole with jfl-chloro-benzoyl chloride affords the ketone Reaction of that... [Pg.234]

Sulfamyl-4-chloro-benzoyl chloride N-Amino-2-methyl indoline... [Pg.808]

A total of 8.9 parts of 3-sulfamyl-4-chloro-benzoyl chloride In a solution of 50 parts of anhydrous tetrahydrofuran are added portionwise in the course of 60 minutes, while stirring, to a solution of 5.2 parts of N-amino-2-methyl indoline and 3.5 parts of triethylamine in 150 parts of anhydrous tetrahydrofuran. The reaction mixture is left to stand 3 hours at room temperature, then the precipitated chlorhydrate of triethylamine is filtered off. [Pg.808]

Another approach for anchoring the carboxyl groups to the aromatic ring of PS is to use a two-step method [35]. In this method, first, the reaction of PS with 2-chloro-benzoylchloride is carried out. The product can then be followed as shown in Scheme (8). If chloro atom is as o-position on benzoyl chloride the reaction occurred as (a). If there is no substitute group o-position on benzoyl chloride, the preferred is reaction (b). [Pg.263]

The reaction232-235 (see also Ref. 236) of 1-diazoketones with hydrogen fluoride that affords 1-fluoro ketones has also been applied to carbohydrates, with, however, no success. Treatment of 3,4-di-O-benzoyl-1-deoxy-l-diazo-D-gfycero-tetrulose with hydrogen fluoride in ether mainly afforded 3,4-di-O-benzoyl-D-gfycero-tetrulose, whereas, with hydrogen bromide and chloride, 3,4-di-O-benzoyl-l-bromo-l-deoxy-and 3,4-di-O-benzoyl-l-chloro-l-deoxy-D-gfycero-tetrulose, respec-... [Pg.243]

Aluminum phosphide Amyl trichlorosilane Benzoyl chloride Boron tribromide Boron trifluoride Boron trifluoride etherate Bromine pentafluoride Bromine trifluoride n-Butyl isocyanate Butyllithium Butyric anhydride Calcium Calcium carbide Chlorine trifluoride Chloro silanes Chlorosulfonic acid Chromium oxychloride Cyanamide Decaborane Diborane... [Pg.61]

Finally, a method of making medazepam from 4-chloro-A -methylaniline is snggested. The last is reacted with ethyleneimine in the presence of alnminum chloride, giving N-(4-chlorophenyl)-iV-methylethylenediamine (5.1.43). Acylation of the resulting product with benzoyl chloride gives the respective amide (5.1.44), which cyclizes into the desired medazepam (5.1.40) using phosphorous oxychloride [44,45],... [Pg.78]

The action of benzoyl chloride on the nitrile-oxide gives the chloro-oxadiazole XXXVII. In this reaction no hydrochloric but benzoic acid is formed (71, 78). [Pg.176]

In general, reactive carbon electrophiles have been shown to react preferentially at the nitrogen atoms of the purine bicycle (see Section 10.11.5.2.1). However, 9-(2,3,5-tris-0-/r /T-butyldimethylsilyl)-a-D-ribofuranosyl-6-chloro-2-(tri-butylstannyOpurine reacted with benzoyl chloride to substitute the 2-tributylstannyl group (PhCOCl, pyridine, toluene, 60% yield) <1997JOC6833>. Indirect C-alkylations have been achieved through deprotonation and alkylation see Section 10.11.5.3.4. The major routes to (7-alkyl and (7-aryl substitution are through nucleophilic displacement or transition metal-catalyzed reactions of halopurines see Sections 10.11.7.4.1 and 10.11.7.4.2. [Pg.543]

Photolysis of 6-chloro-l,3-dimethyluracil (150) with the 1,3,4-oxadiazole 151 afforded the pyrazolo[3,4-d]pyrimidine 152, with photoelimination of benzoyl chloride (80CB2566). [Pg.342]

A reactor packed with FeCl3 supported on A1F3 was preactivated with HF. 2-(Methyl)benzoyl chloride (384 g h 2) and N2 were passed through with C12/HF for approx. 2 h. This gave a mixture (1.03 kg) containing 2-(trifluoromethyl)benzoyl fluoride (8) yield 612 g (70.4%) and a 2-(trifluoromethyl)chloro-benzoyl fluoride byproduct, the structure was not elucidated (13.4%). [Pg.632]

Stoichiometry (28) is followed under neutral or in alkaline aqueous conditions and (29) in concentrated mineral acids. In acid solution reaction (28) is powerfully inhibited and in the absence of general acids or bases the rate of hydrolysis is a function of pH. At pH >5.0 the reaction is first-order in OH but below this value there is a region where the rate of hydrolysis is largely independent of pH followed by a region where the rate falls as [H30+] increases. The kinetic data at various temperatures both with pure water and buffer solutions, the solvent isotope effect and the rate increase of the 4-chloro derivative ( 2-fold) are compatible with the interpretation of the hydrolysis in terms of two mechanisms. These are a dominant bimolecular reaction between hydroxide ion and acyl cyanide at pH >5.0 and a dominant water reaction at lower pH, the latter susceptible to general base catalysis and inhibition by acids. The data at pH <5.0 can be rationalised by a carbonyl addition intermediate and are compatible with a two-step, but not one-step, cyclic mechanism for hydration. Benzoyl cyanide is more reactive towards water than benzoyl fluoride, but less reactive than benzoyl chloride and anhydride, an unexpected result since HCN has a smaller dissociation constant than HF or RC02H. There are no grounds, however, to suspect that an ionisation mechanism is involved. [Pg.235]

V-(4-chloro-2-methylphenyl)benzamide. A mixture of 4-chloro-2-methyl-aniline (14.2 g, 0.10 mol), benzoyl chloride (14.1 g, 0.10 mol) and triethylamine (10.1 g, 0.10 mol) in anhydrous toluene (150 ml) is stirred and refluxed for 3 hours and then allowed to stand for c. 16 hours at room temperature. The resulting solids (mixture of product and salts) are filtered off and stirred at room temperature for c. 1.5 hours with water (150.ml). The solid product is filtered off and recrystallised from dichloromethane-toluene (yield 87%, m.p. 170-171 °C). [Pg.1159]


See other pages where Benzoyl chloride 0-chloro is mentioned: [Pg.28]    [Pg.133]    [Pg.139]    [Pg.90]    [Pg.15]    [Pg.445]    [Pg.275]    [Pg.818]    [Pg.167]    [Pg.227]    [Pg.811]    [Pg.28]    [Pg.133]    [Pg.139]    [Pg.179]    [Pg.183]    [Pg.12]    [Pg.872]    [Pg.2292]    [Pg.55]    [Pg.162]    [Pg.257]    [Pg.179]    [Pg.38]    [Pg.1276]    [Pg.276]    [Pg.301]    [Pg.275]    [Pg.66]    [Pg.89]    [Pg.45]    [Pg.275]    [Pg.253]    [Pg.818]    [Pg.275]   
See also in sourсe #XX -- [ Pg.4 , Pg.28 , Pg.56 ]

See also in sourсe #XX -- [ Pg.4 , Pg.28 , Pg.56 ]

See also in sourсe #XX -- [ Pg.4 , Pg.28 , Pg.56 ]

See also in sourсe #XX -- [ Pg.4 , Pg.28 ]




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Benzoyl chloride

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