Acanthopanax senticosus,

Fujikawa T, Miguchi S, Kanada N, et al. Acanthopanax senticosus Harms as a prophylactic for MPTP-induced Parkinson s disease in rats. J Ethnopharmacol 2005 97 375-381. 

Acanthopanax senticosus (Rupr. et Maxim.) Hams. A. senticosus (Rupr. et Maxim.) var. subinemis (Regel) Kitag. Ci Wu Jia Shao Ci Wu Jia (Siberian ginseng) See Eleutherocossus senticosus ... 

Eleutherocossus senticosus (Rupr. ex Maxim.) Maxim., Acanthopanax senticosus (Rupr. et Maxim.) Harms. 

The Acanthopanax senticosus was purchased from Korea Siberian Ginseng Association(city, Korea). Methanol, acetonitrile and twice distilled water were filtered by using decompressing pump (Division of Millipore, Waters) and filter film(FH-0.S fm)-The extracted sample was concentrated using a rotary evaporator from LABO-THERM SW 200, Resona Technics Co.(city, Korea)... 

Because many kinds of components existed in Acanthopanax senticosus, when the trunk powder of the plant was extracted ethanol, a large amount of impurities were included except for the interest component acanthoside-D. As acanthoside-D is soluble in water, a partitioning step with water/hexane as the partition solvents was used to remove the impurities before further refining. In this procedure, non-polar components were moved into hexane layer and polar components including acanthoside-D were moved into water layer. The water layer was concentrated, and then it was dissolved in methanol and refined by the preparative recycle HPLC. 

A stainless column packed with Lichrospher lOORP-18 was used to analyze Acanthoside-D from the solvent extraction. The composition of mobile phase in analytical HPLC was experimentally determined and it was water/acetonitrile/methanoi=80/14/6 vol.%. From the chromatogram, retention time of Acanthoside-D was found to be 12 min. Figure 1 shows the analysis of Acanthoside-D from the extraction of the trunk of Acanthopanax senticosus. The flow rate of mobile phase and injection volume were 1 nt(/min and 20pl, respectively. 

Figure 1. Analysis of Acanthoside-D from the trunk of Acanthopanax Senticosus (water/acetonitrile /methanol = 80/14/6Vol.%, 20fd injection volume)...

N06B E Psychostimulants that generally increase the physical capacity The medicinal plants that are considered to have this effect and which are described here are Schizandra chinensis, Panax finsen, Eleutherococcus senticosus, (Acanthopanax senticosus), Rhodiola rosea, and Pollen. 

S Nishibe, H Kinosita, H Takeda, G Okano. Phenolic compounds from stem bark of Acanthopanax senticosus and their pharmacological effect in chronic swimming stressed rats. Ghent Pharnt Bull 38 1783-1785, 1990. 

Cui M, Sun WX, Song FR, Liu ZQ, Liu SY (1999) Multi-Stage Mass Spectrometric Studies of Triterpenoid Saponins in Crude Extracts from Acanthopanax senticosus Harms. Rapid Commun Mass Spectrom 13 873... 

The study on influence of Acanthopanax senticosus saponin on blood flow dynamics of isolated working heart showed the saponin had calcium channel blockade action dose-dependently. At concentration of SO, 100 and 200 u g/ml, the saponin reduced the myocardial contractility immediately, after washing out, the action disappeared[38]. 

Acanthopanax senticosus saponin isolated from the leaves at dose of 100, 200mg/kg ip could decrease various cases of experimental hyperglycemias induced by injection of adrenaline, glucose and alloxan, without affecting the levels of blood sugar in normal mice[61]. 

Recently, Acanthopanax senticosus Harms (Araliaceae), so-called Siberian-Ginseng , and Pfaffia paniculata (Matius) Kuntze (Acantha-ceae), so-called Brazilian-Ginseng , have been sold as health foods or for medicinal use similar to that of real Ginseng. It should be noted that the chemical constituents of these two plants are completely different from those of Ginseng and other Panax spp. and that dammarane saponins could not be detected in either of them. 

Figure 2. Separation of Acanthoside-D from the trank of Acanthopanax Senticosus by prq>arative HPLC column... 

Liu Z, Yan G, Bu F, Sun J, Hu X, Zhang H (2005) Analysis of chemical composition of Acanthopanax senticosus leaves applying high-pressure microwave-assisted extraction. Chem Anality 50(5) 851-861... 

Cortex Acanthopanacis Acanthopanax senticosus (Rupr. et Maxim). Maxim. 

Cortex Acanthopanacis, Ciwujia in Chinese, is the root bark of Acanthopanax senticosus (Rupr. et Maxim.) Maxim. (Araliaceae). According to Chinese Medicine, the properties and taste of this drug are pungent, bitter and warm. The drug enters the liver and kidney meridians , dispels wind and dampness, strengthens the tendons and bone, and improves urination [7]. 

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