Aaptos

Utkina, N. K. (2009). Antioxidant activity of aromatic alkaloids from marine sponges Aaptos aaptos and Hyrtios sp. Chem. Nat. Compd. 6, 849-853. 

The Okinawan yellow sponge Aaptos aaptos contained a new type of alkaloid, aaptamine (220), having a 17/-benzo[[Pg.72]

Aaptamine (103), which is a cytotoxic benzonaphthyridine alkaloid isolated from the sponge Aaptos aaptos, induces differentiation in chronic leukemia cells (33). Schulzeine A (104) is a novel dihydroquinoline alkaloids isolated from the sponge Penares schulzei that inhibits glycosidases (12). 

Such behavior may indicate the possibility that one is dealing with a mixture of lectins. Lectins from the snails Axinella polypoides and Aaptos papillata each were found to be mixtures of three lectins, two of which were obtained in purified form the sites of the two lectins from each species showed some differences in specificity, and one of the lectins from Axinella (lectin I) was strongly mitogenic for human peripheral blood T cells and to a lesser extent for human B cells. 

This compound also occurs in a number of related Haplosclerid sponges, such as Topsentia spp., Monanthus ciocalyptoides, Foliolina sp., mdiXestospongia spp., as well as from Aaptos sp., Trachyopsis sp., and two species of Pseudaxynissa... 

C,jH,2N202, Mr 228.25, mp. 110-113 °C. The brilliant green A. wiA a l -benzo[Aaptos aaptos. A. blocks o-adrenoceptois. 

Kudo Y, Kato H, Rotinsulu H, Losung F, Mangindaan REP, de Voogd NJ, et al. Aap-toline A, a new quinoline alkaloid from the marine sponge Aaptos suberitoides. Heterocycles 2014 88(l) 591-4. 

Aaptamine is an alkaloid isolated from the marine sponge Aaptos suberi-toides and it is known to have the ability to upregulate p21 transcription in a p53-independent manner. P-53 is the tumor suppressor, and p21 is a negative regulator of the cell cycle control. Aaptamine derivatives are also... 

Liu CX, Tang XL, Li PL, Li GQ. Suberitine A D, four new cytotoxic dimeric aap-tamine alkaloids fnmt the marine sprmge Aaptos subertoides. Org Lett 2012 14 (8) 1994-7. 

Pham CD, Hartmann R, Muller WEG, de Voogd N, Lai DW, Proksch P. Aaptamine derivatives from the Indonesian sponge Aaptos suberitoides. J Nat Prod 2013 76 (l) 103-6. 

A9, A431 and A549 cell lines, 3478 12a,13a-Aziridinyl epothilone derivatives, 990 Aaptos ciliata, 1292 AATs. See Anthocyanin acyltransferases (AATs)... 

G. E. Herberich, E. Bauer, J. Hengesbach, U. Koelle, G. Huttner, and H. Lorenz, Chem. Ber., 1977, 110, 760. Cyclic analogues of divinyl stannanes, divinyl boranes, and penta-Aapto-divinylborane complexes. 

Nakamura, H., J. Kobayashi, Y. Ohizumi, and Y. Hirata Isolation and Structure of Aaptamine, a Novel Heteroaromatic Substance Possessing a-Blocking Activity from the Sea Sponge Aaptos aaptos. Tetrahedron Lett. 23, 5555 (1982). 

Do, M.N., and K.L. Erickson Branched Chain Mono-Glycerol Ethers from a Taiwanese Marine Sponge of the Genus Aaptos. Tetrahedron Lett. 24, 5699 (1983). 

Harvested initially in the Clenan Archipelago (Southern Brittany) and first regarded as specific to that place, this species would in fact he Aaptos papillata, which is common along the Atlantic and Mediterranean coasts of France. 

A-nor stanols were also found in notable quantities (30% of free sterols) in Aaptos papUlatus (Hadromerida, Suberitidae) harvested in the Mediterranean (Velosaotsy, PhD thesis, Nantes, 2005, and 4th European Conference on Marine Natural Products, Paris, 12-16 September 2000). The genus name Anthoarcuata is one of many synonyms of the genus name Antho, whidi is now the only one accepted in Systema Porifera. 

Aaptos, Anthosigmella, Negombata Glycerol ethers, macrolides, heterocycles... 

Cihatamides A-C are unusual N-methylphenylalanine-containing Hpopeptides isolated from the deep-sea Japanese sponge Aaptos ciliata. Cihatamides A and B were found to be antileishmanial (Nakao et al, 2008). 

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