A Study of Chemokines Post RRV Infection

Caprine Arthritis Encephalitis Virus (CAEV) Offers Compelling Evidence for the Chemokine-Cytokine Basis of Infectious Arthritis 

Like RA, disease post CAEV infection has been associated with a dysregulation of cytokine expression, and with the monocyte/macrophage appearing to be pivotal in disease formation 

Temporal studies have shown that particular cytokines and chemokines are associated with acute or chronic phases of RA, while RRV studies in animals have shown that after severe macrophage associated muscle necrosis post infection, tissue recovery could be observed with a return to normal function, which correlated with the disappearance of monocyte/macrophages from the site of pathology. Therefore, as well as elucidating the role for chemokines in the disease phase of EPA and other infectious arthritidies, future challenges will also center on the function of chemokines and collaborating cytokines in the recovery from arthritic/myalgic disease post infection. 

Study (Ref ) Year of Article (Species) RRV Detected (Method of detection) Tissue Examined/ Pathology Produced Nature of the Cell Infiltrate Associated with Infection/Pathology 

Mims et al. 1973 Yes ( day 1 pi by plaque Brain tissue, serum, muscle/ Monocyte infiltration associated with cortical 

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