A-linked oligosaccharides

Haslam, S.M., Coles, G.C., Munn, E.A., Smith, T.S., Smith, H.F., Morris, H R. and Dell, A. (1996) Haemonchus contortus glycoproteins contain A-linked oligosaccharides with novel highly fucosylated core structures. Journal of Biological Chemistry 271, 30561—30570. 

Kang, S., Cummings, R.D. and McCall, J.W. (1993) Characterization of the A-linked oligosaccharides in glycoproteins synthesised by microfilariae of Dirofilaria immitis. Journal of Parasitology 79, 815-828. 

Bisected biantennary core structure of the A-linked oligosaccharides... 

Golgi a-l)-mannosidase II lysosomal mannosidase glycoprotein A-linked oligosaccharide processing [toxic, neurotoxic effects mimic hereditary lysosomal storage disease mannosidosis] (3-D-Glucuronidase cx-1-iduronidase Glucosidase... 

Figure 11.19. -linked oligosaccharides. A pentasaccharide core (shaded yellow) is common to all A-linked oligosaccharides and serves as the foundation for a wide variety of A-linked oligosaccharides, two of which are illustrated (A) high-mannose type (B) complex type. Detailed chemical formulas and schematic structures are shown for each type. 

The second family of A-linked oligosaccharides are called the lactosamine family in which the D-mannose residues of the core pentasaccharide are substituted 1 2 by lactosamine, which is a lactose analogue with A-acetyl-D-glucosamine substituted for D-glucopyranose at the reducing-end of lactose. The lactosamine is frequently substituted by A-acetyl-D-neu-raminic acid (for the structure of A-acetyl-D-neuraminic acid, see the monomer residue in colominic acid,0 Sect. 8.2 andO Fig. 7) linked 2 3 or 2 6 [142,143]. The third family has a mixed structure of the high mannose and lactosamine families [144,145,146,147]. 

Skeletal keratan sulfate and comeal keratan sulfate are linked to core protein through 0-linked and A-linked oligosaccharides, respectively, of the general types described in O Sect. 2.4 and O Sect. 2.5. 

I. Tvaroska and F. R. Taravel, One-bond carbon-proton coupling constants Angular dependence in a-linked oligosaccharides, Carbohydr. Res., 221 (1991) 83-94. 

VanderElst I, Dennis JW (1991) A -Linked oligosaccharide processing and autocrine stimulation of tumor cell proliferation. Exp Cell Res 192 612-621... 

A Preformed A/-Linked Oligosaccharide Is Added to Many Proteins in the Rough ER... 

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