A Comparison of Protein Structure Prediction Methods CASP

8 A Comparison of Protein Structure Prediction Methods CASP 

The utility of a protein model depends upon the use to which it is put. In some cases, one is only interested in the general fold that the protein adopts and so a relatively low-resolution structure is acceptable. For other applications, such as drug design, the model must be much more accurate, including the loops and side chains. In such cases, a poor model may often be far worse than no model at all, as it can be seriously misleading. 

One disturbing finding was that a significant proportion of the models contained errors, even including amino acids with the wrong stereochemistry. In addition, significant deviations 

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