A brief history of pharmacokinetics

The mathematics of pharmacokinetics strongly resembles, and arises from, the mathematics of chemical kinetics, enzyme kinetics, and radioisotope (tracer) kinetics. Table 2.1 shows how, over the years, the mathematical theory of pharmacokinetics and that of its older siblings has been substantiated by experimental work. In fact, substantiation of a particular kinetic theory often 

1850 First experimentally determined chemical reaction rate (hydrolysis of sucrose in solution rotation of polarized light changing over time) 

1953 First pharmacokinetic book, Der Blutspiegel by Dost, expands pharmacokinetics  

1966 Drugs and Tracer Kinetics by Rescigno and Segre published  

1975 First pharmacokinetics textbook published Pharmacokinetics by Gibaldi and Perrier  

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