A?-Androstene-17-one

FluoFO-2-aldehydotestosterone, 804 3 Fluoro-A -androstene-17-one, 249 16ot-Fluoro-A -androsteiie-17-one, 804 p-Fluoroaniline, 280 p-Fluorobenzaldehyde, 1058 Fluorobenzene, 43, 238, 394, 845... [Pg.713]

Backbone rearrangements of various steroidal amines have been carried out in order to study the mechanism and to elucidate the stereochemistry of the rearranged products. The two 3 -dimethylamino-A -androsten-17-ones epi-meric at position 14, (33) and (34), when treated with concentrated sulphuric... [Pg.265]

Noguchi and Fukushima (1966) have isolated and characterized, by infrared, NMR, and mass spectrometry and chemical techniques, a highly polar metabolite, 3a-ureido-ll/S-hydroxy-A -androsten-17-one, from the urine of normal healthy subjects, a substance which is materially increased in patients with myxedema. Infrared spectroscopy helped to eliminate an alternate structure, a pseudourea derivative. The compound found was given the trivial name of ureasterone (LXXXIII). [Pg.343]

Chloro-A -androsten-17-one, VII, 343 Chloroform, glycosuria and, X, 209 3/3-Chlorooholestane, configuration, determination by X-ray analysis, VIII, 283 21-Chloroprogesterone, effect on D-amino acid oxidase, X, 357 Cholane,... [Pg.259]

The transformation products introduced during acid hydrolysis are products of dehydration, halogenation, and rearrangement. Dehydration may occur at sites distant from the carbon atom involved in the conjugate as in the formation of A <">-androstene-3a-ol-17-one and -etiocholene-3a-ol-17-one from the corresponding ll 3-hydroxy compounds (83). It may also occur during the course of the hydrolysis of a sulfate ester as in the conversion of androsterone sulfate to A -androstene-17-one (126). [Pg.489]

Dehydroisoandrosterone (XXXI, 3 8-hydroxy-A -androstene-17-one, cf. Table VI) is a weakly androgenic steroid found in small amounts in the... [Pg.395]

Treatment of the 4-oxasteroid 467 with Lawesson s reagent effects the simultaneous O—>S conversion and dehydration of the hemiacetal unit to give the 4-thia-5-androstene-17-one in 40% yield. Subsequent hydrogenation results in a (3 2) mixture of the 4-thia-5-ot- and 5-(3-androstane-17-ones (Scheme 161) <2005T3691>. [Pg.885]

SYNS (3-p,5-a)-3-(ACETYLOXY)ANDROSTAN-17-ONE ANDROSTAN-17-ONE, 3-(ACETYLOXY)-, (3-P,5-a)- DEHYDROEPIANDROSTERONE ACETATE EPIANDROSTERONE, DEHYDRO-, ACETATE ANDROSTEN-17-ONE, 3-p-HYDROXY-, ACETATE... [Pg.750]

ANDROST-4-EN-17 J-OL-3-ONE see TBF500 A -ANDROSTEN-17(P)-OL-3-ONE see TBF500 ANDROSTEN-17-ONE, 3-P-HYDROXY-, ACETATE see HJB225... [Pg.1514]

The metabolism of 17)3-hydroxy-l-methyl-A -androstene-3-one is markedly different from that of testosterone. In addition to the large amount of unchanged compound, small amounts of l-methyl-A -andro-stene-3,17-dione and la-methyl-androstane-3,17-dione also are excreted in the urine, but the 1-methylated androsterone or etiocholane derivatives are not found [275]. [Pg.27]

Metabolism studies. GC-MS is a powerful technique for following and identifying the metabolic products from the in vitro incubation of tissue preparations with steroid substrates. Examples of such studies include the 16a-hydroxylation of 18-hydroxydeoxycorticosterone by human adrenal gland [254], the eiromatization of 3jS,15, 16 -trihydroxy-5-androsten-17-one by placental homogenates [255], and the demonstration of 1/3, 12/3, 6a and 6/3 hydroxylase enzyme activities in microsomal preparations of human foetal hepatic tissue [256]. In the latter study, testosterone was used as substrate and in addition to the hydroxylated metabolites isolated, several other testosterone derivatives indicated the presence of 3a, 3/3 and 17/3-hydroxysteroid oxidoreductase in the adrenal gland preparation. [Pg.51]

Hydroperoxy-2-nitropropane, 256 p-Hydroquinone, 331,393,418 p-Hydroquinone dimethyl ethers, 432 Hydroquinones, 72 Hydrosilylation, 562 Hydroxamic acids, 204 2-Hydroximino-l-phenylpropane, 124 ai-Hydroxyacetophenone, 342 (3-Hydroxyacetylenes, 144-145 a-Hydroxy acids, 492 (5-Hydroxy acids, 301 1-Hydroxyadamantane, 126 a-Hydroxyaldehydes, 342 3o-Hydroxy-5a-androstene-17-one, 227-228... [Pg.325]

Perelman et aV of Eli Lilly and Co. found that the 19-nor-A -sleroid (1,19-nor-A < -androstene-17 3-ol-3-one) can be dehydrogenated smoothly to the 19-nor-A -3-ketosteroid (2) by reaction with bromine in pyridine or, more conveniently. [Pg.487]

The Palo Alto Syntex Research group8 effected addition of difluorocarbene to th double bond of 17/3-hydroxy-5a-A -androstene-3-one acetate (1) by drop wise addition of a saturated solution of 20-50 equivalents of sodium chlorodifluoroacetate in diglyme or triglyme to a 10% solution of the enone in the same solvent at 165-... [Pg.194]

Names Sl synonyms TESTOSTERONE ENANTHATE testosterone heptanoate 17 >hydroxyandrost 4 n 3-one-17-enanthate. TESTOSTERONE PHENYLACETATE l7 hydroxy-4-androsten-3K>ne phenyl-acetate testosterone < toluatc. TESTOSTERONE PROPIONATE A -androstene 17 propionatc 3-one. [Pg.2639]

Prochazka and colleagues (P-741) have reported the formation of a 5,6-oxide of unspecified configuration from the action of Rhizopus nigricans on 3/3-hydroxy-B-npr-5-androsten-17-one. Based on the known ability of Rhizopus sp. to 6/3-hydroxylate, we think the oxide must be 5/3,6/3. This is consistent with the observed formation, in... [Pg.44]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...