A. altilis

The cytoprotective effects of various solvent extracts of Artocarpus altilis (Parkinson) Fosberg were evaluated. These effects were determined in human U937 cells incubated with oxidized LDL (OxLDL) using the 4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-l, 3-benzene disulfonate (WST-1) assay. Results demonstrated that the EtOAc extract showed cytoprotective activities. To identify the main cytoprotective components, a bioassay guided isolation of the ethyl acetate extract afforded P-sitosterol and six flavonoids. Their chemical structures were established on the basis of spectroscopic evidence and comparison with literature data. One of these compounds was obtained from A. altilis for the first time. The cytoprotective effect offers good prospects for the medicinal applications of. Altilis [34]. 

Hexane extract of A. altilis at high concentration (O.lg/ml) E. coli No Inhibition 0 0... 

Ethanol extracts of A. altilis + Brassica rapa chinensis at high concentration O.lg/ml E. coli 11mm, 11mm, 10mm 10.67 0.58 89.4... 

Figure 9. Antimicrobial activity of CH2CI2 extract of A. altilis at a concentration of O.Olg/ml, 0.05g/ml and 0.1 g/ml.

Further antimicrobial selectivity is seen for the CH3CH2OH extract of Brassica rapa chinensis at a concentration of O.Olg/ml against E. coli and Bacillus subtilis. For the former, AZOI of 209.37 mm is noted, whereas for the latter, AZOI of 12.56 mm was registered. Again for the CH3CH2OH extract, A. altilis at a concentration of O.Olg/ml showed antimicrobial selectivity against E.coli, S.aureus and Bacillus subtilis over C. albicans. For the latter, zero AZOI was observed whereas for the first three, AZOI, ranging from 46.7 mm to 95.00 mm were observed. 

Thus, for Brassica rapa chinensis, extract at low concentration showed the solvent type extract selectivity CH3CH2OH > n-CgHi4. For A. altilis, at a low concentration, the solvent type extract showed the selectivity of CH3CH2OH > CH2CI2 > n-C6Hi2. The n-CeH extract of Brassica rapa chinensis should be more selective for S.aureus, C. albicans infection whereas the CH3CH2OH extract of Brassica rapa chinensis should be more suited against... 

E.coli and C. albicans infection. The CH3CH2OH extract of A. altilis at low concentration should be suited for S. aureus infection. 

Figure 12. Antimicrobial activity of the combined ethanol and hexane extract of A. altilis and Brassica rapa chinensis at high concentration.

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