3H-Dopamine

Lonart G, Johnson KM Inhibitory effects of nitric oxide on the uptake of [3H]dopamine and [3H]glutamate by striatal synaptosomes. J Neurochem 63 2108—2117, 1994 Lovinger DM, White G Ethanol potentiation of 5-hydroxytryptamine3 receptor-mediated ion current in neuroblastoma cells and isolated adult mammalian neurons. Mol Pharmacol 40 263—270, 1991... 

Johnson, K.M., and Snell, L.D. Effects of phencyclidine (PCP) -like drugs on turning behavior, 3H-dopamine uptake, and 3H-PCP-binding. Pharmacol Biochem Behav 22 731-735, 1985. 

Vickroy, T.W., and Johnson, K.M. In vivo administration of phencyclidine inhibits 3H-dopamine accumulation by rat brain striatal slices. Subst Alcohol Actions Misuse 1 351-354, 1980. Vickroy, T.W.,and Johnson, K.M. Similar dopamine-releasing effects of phencyclidine and nonamphetamine stimulants in striatal slices. J. Pharmacol Fxp Ther 223 669-674, 1982. 

This benzylisoquinoline alkaloid inhibits in vitro the specific bonding of [3H] dopamine to dopamine receptors and abrogates amphetamine-induced circling behavior in rodents with unilateral degeneration of dopaminergic neurons in the corpus striatum (109). 

Heikkila, R.E., Manzino, L., and Cabbat, F.S., Stereospecific effects of cocaine derivatives on 3H-dopamine uptake correlations with behavioral effects, Subst. Use Misuse, 2, ff5, f98f. 

Masuoka, D.T., Alcaraz, A.R, and Schott, H.F., [3H]Dopamine release by d-amphetamine from striatal synaptosomes of reserpinized rats, Biochem. Pharmacol., 31, 1969, 1982. 

Liang, N.Y. and Rutledge, C.O., Comparison of the release of [3H]dopamine from isolated corpus striatum by amphetamine, fenfluramine and unlabeled dopamine, Biochem. Pharmacol., 31, 983, 1982. 

Jacocks, H.M. and Cox, B.K., Serotonin-stimulated [3H]dopamine via reversal of the dopamine transporter in rat striatum and nucleus accumbens a comparison with release elicited by potassium, N-methyl-D-aspartic acid, glutamic acid and D-amphetamine, J. Pharmacol. Exp. Ther., 262, 356, 1992. 

Das, D., Rogers, J., and Michael-Titus, A.T., Comparative study of the effects of mu, delta and kappa opioid agonists on 3H-dopamine uptake in the rat striatum and nucleus accumbens, Neuropharmacology, 33, 221, 1994. 

Mount, H., Boksa, P., Chadieu, I., and Quirion, R., Phencyclidine and related compounds evoked [3H] dopamine release from rat mesencephalon cell cultures by mechanisms independent of the phencyclidine receptor, sigma binding site, or dopamine uptake site, Can. J. Physiol. Pharmacol., 68,1200,1990. 

Baba, A., Yamamoto, T., Yamamoto, H., Suzuki, T., and Moroji, T., Effects of the major metabolite of phencyclidine, the trans isomer of 4-phenyl-4-(l-piperidinyl) cyclohexanol, on [3H]N-(l-[2-thie-nyl]cyclohexyl)-3,4-piperidine([3H TPC) binding and [3H] dopamine uptake in the rat brain, Neurosci. Lett., 182, 119, 1994. 

Samuel, D., Lynch, M.A., and Littleton, J.M., Picrotoxin inhibits the effect of ethanol on the spontaneous efflux of [3H]-dopamine from superfused slices of rat corpus striatum, Neuropharmacology, 22, 1412, 1983. 

Westfall, T.C., Effect of nicotine and other drugs on the release of 3H-norepinephrine and 3H-dopamine from rat brain slices, Neuropharmacology, 13, 693, 1974. 

Marien, M., Brien, J., and Jhamandas, K., Regional release of [3H]dopamine from rat brain in vitro effects of opioids on release induced by potassium nicotine, and L-glutamic acid, Can. J. Physiol. Pharmacol., 61, 43, 1983. 

Dwoskin, L.P., Leibee, L.L., Jewell, A.L., Fang, Z., and Crooks, P.A., Inhibition of [3H]dopamine uptake into rat striatal slices by quaternary V-methylated nicotine metabolites, Life Sci., 50, PL-223, 1992. 

Grady, S.R., Marks, M.J., Collins, A.C. Desensitization of nicotine-stimulated [3H]dopamine release from mouse striatal synaptosomes. J. Neurochem. 62 1390, 1994. 

Snyder, S.H., Coyle, J.T. Regional differences in 3H-norepinephrine and 3H-dopamine uptake into rat brain homogenates. J. Pharmacol. Exp. Ther. 165 78, 1969. 

Fig. 3. Evidence for an endogenous Zn2+-binding site in the DAT but not in the NET. (A) Zn2+ inhibition of [3H]dopamine uptake in COS-7 cells transiently expressing hDAT (filled circles) or hNET (open circles). (B) Effect of Zn2+ on binding of the cocaine analog [3H]WIN 35,428 to hDAT (filled circles) and hNET (open circles). Values are percent of control ([3H]dopamine uptake or [3H] WIN 35,428 binding in the absence of Zn2+) expressed as means S.E. of 3-5 experiments performed in triplicate.

Mutation to leucine in GAT of a highly conserved tryptophan, W681.50, disrupted the release of substrate to the intracellular medium, and the authors inferred from this that TM1 is involved with substrate interactions (58). Mutation to alanine of Pro87i.53 in TM1 or Prol 122.5o in TM2 increased the Km for [3H]dopamine uptake 21-fold and 17-fold, respectively, consistent with either a direct or indirect effect on dopamine binding... 

Ary, T. E., and Komiskey, H. L. (1982) Phencyclidine-induced release of (3H)dopamine from chopped striatal tissue. Neuropharmacology, 21 639-645. 

Sakurai Y, Takano Y, Kohjimoto Y, Honda K, Kamiya HO. (1982). Enhancement of [3H]dopamine release and its [3H]metabolites in rat striatum by nicotinic drugs. Brain Res. 242(1) 99-106. Schechter MD. (1990). Rats become acutely tolerant to cathine after amphetamine or cathinone administration. Psychopharmacology (Berlin). 101(1) 126-31. 

Teng L, Crooks PA, Dwoskin LP. (1998). Lobeline displaces [3H]dihydrotetrabenazine binding and releases [3H]dopamine from rat striatal synaptic vesicles with d-amphetamine. J Neurochem. 71(1) 258-65. 

Teng L, Crooks PA, Sonsalla PK, Dwoskin LP. (1997). Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine differential inhibition of synaptosomal and vesicular [3H]dopamine uptake. J Pharmacol Exp Ther. 280(3) 1432-44. 

Dennis J. McKenna, X.-M. Guan, and A. T. Shulgin. "3,4-methyl-enedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine." Pharmacology, Biochemistry, and Behavior 38 (1991) 505-12. 

EGb inhibits the uptake of [3H]norepinephrine ([3H]NE) and [3H]dopamine and [3H]5-hydroxytryptamine ([3H]5-HT) into in vitro synaptosomes prepared from the striatum and cortex in a concentration-dependent manner. The rank order of potency for the inhibition of amine uptake is NE > dopamine > 5-HT [173]. Similar results were obtained by Ramassamy et al. [174]. These workers showed that EGb decreased the specific uptakes of [3H]dopamine, [3H]5-HT and [3H]choline by synaptosomes prepared from the striatum of mice in a concentration-dependent manner. The IC,0 values were 637 pg/rol for [3H]dopamine uptake, 803 pg/ml for [3H]5-HT uptake, >2000 pg/ml for [3H]choline uptake. However, they concluded that the inhibition of amine uptake caused by EGb appears to be non-specific, since EGb also prevents the specific binding of the dopamine uptake inhibitor [3H]GBR12783 to membranes prepared from striatum. 

L. Soliakov, T. Gallagher and S. Wonnacott, Anatoxin-a-evoked 3H dopamine release from rat striatal synaptosomes, Neuropharmacology, 34... 

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