Zometa - Zoledronic acid

Zoledronic acid (Zometa , available as generic) 4-8 mg Days Weeks 1-5 mg/dL... 

AP23451 administration to mice inoculated with MDA-231 breast cancer cells effectively prevents metastasis-induced osteolysis similar to bisphosphonate zoledronic (Zometa ). However, it also significantly reduces the volirme of tumor cells inside the bone marrow cavities of the mice as opposed to a lack of inhibitory effect on tirmor cell volume in mice treated with zoledronic acid. AP23588 is also a bone-targeted Src kinase inhibitor which has been determined to possess both anti-resorptive and anabohc properties in vitro with respect to reducing osteoclast activity and stimulating osteoblast activity, respectively. 

Powder for injection 4 mg zoledronic acid anhydrous Rx) Zometa (Novartis)... 

Teriparatide (Forteo) Zoledronic acid (Zometa, Reclast)... 

The bisphosphonates are the most effective compounds available to treat hypercalcemia of malignancy. Pamidronate (Aredia) and zoledronic acid (Zometa) can be infused intravenously and are the most effective compounds available for rapid reduction of serum calcium levels. 

Zoledronic acid (zometa) is a bisphosphonate (see Chapter 61) indicated for the treatment of patients with bony metastases and for patients with MM. A direct antitumor effect on myeloma cells has been proposed some data suggest that inhibition of bone matrix-degrading proteinases may inhibit tumor ceU invasion in breast and prostate cancers. 

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