Zocor

The cholesterol-lowering agents called statins, such as simvastatin (Zocor) and pravastatin (Pravachol), are among the most widely prescribed drugs in the world. Identify the functional groups in both, and tell how the two substances differ. [Pg.105]

D Denan (Boehringer Ing. GB Zocor (Merck Sharp Sivastin (Sigma-Tau)... [Pg.1878]

Zocor (Dieckmann 1990) 1 Lipoiiorm (Gentili) J Lipovas (Banyu)... [Pg.1878]

F Lodales (Sanofi Winthrop) Medipo (Mediolanum) USA Zocor (Merck)... [Pg.1878]

Metformin 1000 mg PO twice daily Metoprolol XL 50 mg PO once daily Zocor 20 mg PO once daily... [Pg.783]

Zocor (Simvastatin) Hypercholesterolemia Hyperlipoproteinemia Hypertriglyceridemia 3.9 1.3 1989 - UK 1991 - US Once daily... [Pg.135]

Zn-SPS ionomer, 74 479 Zn sulfo-EPDM ionomers, 74 483 Zn-sulfonated polystyrene (ZnSPS) ionomer, 74 465 Zocor, 5 143... [Pg.1040]

Baycol (cerivastatin, sold as Lipobay in Europe, Bayer) is a statin, a class of cholesterol-lower drugs. Statins are the most prescribed drugs in the United States, with more than 12 million people taking them, and more than 700,000 people in the United States taking cerivastatin. It received marketing approval on June 26, 1997 and was voluntarily removed from the market on August 8, 2001 because of its link to 100 deaths and several injuries from potentially the muscle disease rhabdomyolysis. The other statins — lovas-tatin (Mevacor Merck) pravastatin (Pravachol Bristol-Myers Squibb) simvastatin (Zocor Merck) fluvastatin (Lescol Novartis) atorvastatin (Lipitor Parke-Davis) rosuvastatin... [Pg.515]

Most of us are familiar with the effects of cholesterol. Exhibit 1.3 provides an explanation of how cholesterol is formed and the mechanism of action for Lipitor and Zocor in lowering the sterol. [Pg.7]

An enzyme (see Section 2.6) called HMG-CoA reductase is involved in the biosynthesis of cholesterol. Drugs such as atorvastatin (Lipitor) and simvastatin (Zocor) are competitive inhibitors of HMG-CoA reductase. They inhibit cholesterol synthesis by increasing the number of LDL receptors to take up the LDL. [Pg.8]

Atorvastatin (Lipitor, Pfizer) and simvastatin (Zocor, Merck) HMG-coenzyme A inhibitors for the reduction of cholesterol level in blood (refer to Exhibit 1.3). [Pg.36]

Simvastatin (Zocor, Pfizer) Cardiovascular Enzyme inhibitor... [Pg.40]

A 42-year-old man presents with a chief complaint of intermittent claudication during exercise. His fomHy history is significant for the presence of cardiovascular disease on his fether s side, but not on his mother s side. Physical exam reveals xanthelasmas and bilateral tendon xanthomas. A plasma lipid profile reveals a cholesterol level of 340 mg/dL, with a high LDL/HDL ratio. He is given instructions for dietary modifications and a prescription for Zocor (simvastatin). [Pg.223]

A number of cholesterol-lowering drugs (Pravachol, zocor, and mevacor) are prepared by enzymatic processes. Penicillin antibiotics that have been on the market for decades are produced in large quantities by the enzymatic process. [Pg.245]

The most important class of cholesterol-lowering agents is the statins. These include lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), and atorvastatin (Lipitor), among others. These molecules work, in modest part, by inhibiting biosynthesis of cholesterol and, in larger part, by increasing the rate at which cholesterol is eliminated by the body. Let s have a look at this in more detail. [Pg.268]

Zinacef 22 Zithromax 17 Zocor 61 Zofran 53 Zdmitriptan 69 Zoloft 61 Zolpidem 69 Zomig 69 Zostrix 21 Zosyn 84 Zovirax 12 Zyban 19 Zyflo 69 Zyloprim 14 Zyprexa 53 Zyrtec 23... [Pg.84]

The brand-name drug products included in the study represent some of the largest drug products as measured by annual sales. They include blockbuster drugs such as Capoten, Cardizem CD, Cipro, Claritin, Lupron, Neurontin, Paxil, Pepcid, Pravachol, Prilosec, Procardia XL, Prozac, Vasotec, Xanax, Zantac, Zocor, Zoloft, and... [Pg.4]

Prilosec, Procardia XL, Prozac, Vasotec, Xanax, Zantac, Zocor, Zoloft, and Zyprexa. [Pg.27]

Omega-3 Fatty Acid [Fish Oil] (Lovaza) Pravastatin (Pravachol) Rosuvastatin (Crestor) Simvastatin (Zocor)... [Pg.41]

The first generation of statins to be approved for the treatment of hypercholesterolemia was based upon the natural product compactin, an HMG-CoA reductase inhibitor originally isolated from cultures of Penicillium. The most widely prescribed of these first-generation statins are simvastatin (4, Fig. 12.2), marketed as Zocor , and pravastatin (5), marketed as Pravacol . Based in large part on the clinical effectiveness of these early... [Pg.170]

See also in sourсe #XX -- [ Pg.268 ]

See also in sourсe #XX -- [ Pg.283 ]

See also in sourсe #XX -- [ Pg.170 ]

See also in sourсe #XX -- [ Pg.18 , Pg.20 ]

See also in sourсe #XX -- [ Pg.1131 ]

See also in sourсe #XX -- [ Pg.3 , Pg.8 , Pg.43 ]

See also in sourсe #XX -- [ Pg.103 ]

See also in sourсe #XX -- [ Pg.283 ]

See also in sourсe #XX -- [ Pg.373 , Pg.374 ]

See also in sourсe #XX -- [ Pg.103 ]

See also in sourсe #XX -- [ Pg.8 ]

See also in sourсe #XX -- [ Pg.334 ]

See also in sourсe #XX -- [ Pg.3 , Pg.3 , Pg.343 , Pg.609 ]

See also in sourсe #XX -- [ Pg.164 ]

See also in sourсe #XX -- [ Pg.656 ]

See also in sourсe #XX -- [ Pg.6 , Pg.7 , Pg.31 ]

See also in sourсe #XX -- [ Pg.6 , Pg.9 ]

See also in sourсe #XX -- [ Pg.614 ]

See also in sourсe #XX -- [ Pg.283 ]

See also in sourсe #XX -- [ Pg.211 ]

See also in sourсe #XX -- [ Pg.779 ]

See also in sourсe #XX -- [ Pg.334 ]

See also in sourсe #XX -- [ Pg.138 , Pg.1198 ]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...