Ziprasidone Quinidine

Antipsychotics produce more important pharmacodynamic than pharmacokinetic interactions because of their multiple effects. Additive effects may occur when these drugs are combined with others that have sedative effects, a-adrenoceptor-blocking action, anticholinergic effects, and—for thioridazine and ziprasidone—quinidine-like action. 

Drugs that may affect disopyramide include antiarrhythmics, beta blockers, cisapride, clarithromycin, erythromycin, fluoroquinolones, hydantoins, quinidine, thioridazine, rifampin, verapamil, and ziprasidone. Drugs that may be affected by disopyramide include quinidine, anticoagulants, and digoxin. 

Clinically important, potentially hazardous interactions with amiodarone, azithromycin, bepredil, bosentan, bretylium, cisapride, clarithromycin, disopyramide, erythromycin, erythromycin fluconazole, fluoxetine, fluvoxamine, grapefruit juice, indinavir, itraconazole, ketoconazole, metronidazole, miconazole, nefazodone, nilotinib, paroxetine, pimozide, probucol, procainamide, quinidine, quinine, ritonavir, saquinavir, sertraline, sotalol, SSRIs, terfenadine, troleandomycin, voriconazole, zileuton, ziprasidone... 

Clinically important, potentially hazardous interactions with amiodarone, arsenic, bepridil, bretylium, disopyramide, erythromycin, nilotinib, phenothiazines, procainamide, quinidine, sotalol, tricyclic antidepressants, zinc, ziprasidone, zuclopenthixol... 

Clinically important, potentially hazardous interactions with cyclosporine, diltiazem, dofetilide, erythromycin, grapefruit, ketoconazole, quinidine, ritonavir, simvastatin, sotalol, thioridazine, verapamil, ziprasidone... 

QTc-prolonging drugs Sertindole is contraindicated in patients receiving drugs known to prolong the QTc interval, such as amiodarone, astemizole, quinidine, sotalol, thioridazine, and ziprasidone.i 7... 

May enhance QTc effects with alfuzosin, ciprofloxacin, cisapride, dronedaron, lumefantrine, nilotinib, quinidine, tetrabenazine thioridazine, ziprasidone. 

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