Ziprasidone mesylate

Sulfobutylether-p-cyclodextiin (Captisol ) is one of newest excipients in pharmaceutical commercial formulations, is very safe, chemically stable, water-soluble, and is an excellent solubilizing drug delivery technology for molecules in which it forms an inclusion complex. An aqueous solution with 12%wt/v Captisol is isotonic, but formulations can contain as much as 30%wt/v Captisol. Ziprasidone mesylate, a rapid... 

Despite the potential advantage of salt formation, many compounds do not form salts. Even when salts are formed, they may have limited aqueous solubility. For example, aqueous solubilities of hydrochloride and mesylate salt forms of the weakly basic drug ziprasidone were 80 and 890 ttg/mL, respectively, and, because of such low solubility, the dissoiution of salts was incomplete, and the human bioavailability was variable (Thombre et al. 2011). There is also the potential that the salts may convert to the less soluble free base or acid form in the diffusion layer, thus coating the surface of the dissolving solid, and preventing further dissolution of the salt (Serajuddin 2007). 

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