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Zinc-ligand interactions phosphate

The rate of hydrolysis of bis(4-nitrophenyl) phosphate is approximately 10-fold higher for a binuclear Zn2(OH)2 complex of the L22 ligand (Fig. 52) versus a mononuclear zinc hydroxide complex of the L23 ligand at 308 K.105 In this system, a monohydroxide binuclear zinc complex (Zn2(p-OH)) does not promote phosphate diester hydrolysis. The 10-fold rate enhancement found for the reaction involving the binuclear Zn2(OH)2 complex was explained via cooperative interaction between the zinc centers. As shown in Fig. 54, the reaction is proposed to take place via attack of a terminal Zn-OH moiety on a phosphate diester substrate that is interacting with both zinc centers. This suggests a cooperative role for the two zinc centers in the phosphate diester hydrolysis reaction. [Pg.151]

A. The multisystem toxicity of lead is mediated by several mechanisms, including inactivation or alteration of enzymes and other macromolecules by binding to sulfhydryl, phosphate, or carboxyl ligands, and interaction with essential cations, most notably calcium, zinc, and iron. Pathological alterations in cellular and mitochondrial membranes, neurotransmitter synthesis and function, heme synthesis, cellular redox status, and nucleotide metabolism may occur. Adverse impacts on the nervous, renal, hematopoietic, reproductive, and cardiovascular systems can result. [Pg.238]

Metal ions bind to both phosphate and base sites on the nucleic acid molecules, and each type of binding results in characteristic ligand reactions. Many metals bind to both types of sites. Among these is zinc(II), and we shall therefore concentrate our attention on the interactions of this metal ion with nucleic acids. [Pg.101]


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See also in sourсe #XX -- [ Pg.290 , Pg.291 , Pg.292 , Pg.293 , Pg.294 ]




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