Zinc finger proteins gene expression

Transcription factors that upregulate strictosidine synthase (132), as well as a transcription factor that coordinately upregu-lates expression of several terpenoid indole alkaloid biosynthetic genes, have been found (133). Several zinc finger proteins that act as transcriptional repressors to tryptophan decarboxylase and strictosidine synthase also have been identified (134). Manipulation of these transcription factors may allow tight control of the regulation of terpenoid indole alkaloid production. Interestingly, expression of a transcription factor from Arabidopsis thaliana in C. roseus cell cultures results in an increase in alkaloid production (135). 

A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYPllAl gene expression. J. Biol. Chem. 276,33881-33892. 

Adachi H, Tsujimoto M. Characterization of the human gene encoding the scavenger receptor expressed by endothelial cell and its regulation by a novel transcription factor, endothelial zinc finger protein-2. The Journal of Biological Chemistry 2002,211 24, 014-24,021. 

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