Yes-associated protein

Espaniel, X. and Sudol, M. (2001) Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains../. Biol. Chem. 276, 14514-14523. 

Sudol, M. (1994). Yes-associated protein (YAP65) is a proline-rich phosphoprotein that binds to the SH3 domain of the Yes proto-oncogene product. Oncogene 9, 2145-2152. 

YAP/TAZ Yes-associated protein/transcriptional coactivator with PDZ binding... 

Since other membranes have an integral transmembrane electron transport system, the question arises whether these electron carriers can be involved in an oxidation-reduction driven proton movement. In neutrophil as well as macrophage plasma membranes, the answer is already yes. The superoxide-producing NADPH oxidase in these membranes is associated with a channel for proton movement to accompany the electron flow when internal NADPH is oxidized by external oxygen to produce superoxide (Nanda et al., 1993). This is a relatively simple electron transport system which contains a heterodimeric cytochrome b which also binds flavin. Thus, two proteins in a transmembrane electron transport system can transfer protons across the membrane. 

Yes, a number of human diseases are caused by point mutations in the promoter regions of important genes. For example, /3-thalassemia is a genetic disease in which mutations in the promoter of the /3-globin gene result in reduced production of this protein and subsequent anemia. The mutation is usually associated with a reduction in the binding affinity of the promoter for a positive transcription factor. 

Many characterized INM proteins have been shown to interact with lamins (Ye et al. 1998). For the subset of putative NETs that share this characteristic, a more definite result can be achieved. As previously discussed, the lamin polymer is insoluble to extraction with detergent and salt therefore retention of NETs in cells extracted with detergent (e.g. 0.5% Triton X-100) prior to fixation for microscopy confirms their direct, or indirect, association with the lamin polymer and NE localization. However, loss of the protein to a pre-extraction with detergent would occur for proteins not tethered to the lamin polymer whether they are normally localized to the INM, ONM, or ER. All eight of the putative NETs originally tested targeted to the NE, but only five remained at the NE after the detergent pre-extraction (Schirmer et al. 2003). 

Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS Membrane glycoprotein IV (CD36) is I iysically associated with fyn, lyn and yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A 88 7844-7848,1991... 

Available models include both binary ( yes or no predictions, reported as probability of yes ) and quantitative value models (e.g., for inhibition constants in pM). The range of values considered as a hit for the QSAR model (and therefore defining a compound-protein association for binding type models) is user selectable (Fig. 4). The default values are 0.5-1 for binary models (i.e., >50% probability of a positive match to the model) and 50 pM - the lowest limit of the training set activity for binding activity models. Other model types (e.g., % serum protein binding) have default values appropriate for the model and the training set see Note 1). 

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